Citas bibligráficas
Rebolledo, K., (2021). Asociación entre tiempo de abandono y falla terapéutica en adultos inmigrantes venezolanos con infección por el Virus de Inmunodeficiencia Humana que reinician Terapia Antirretroviral de Gran Actividad atendidos en el Hospital Nacional Arzobispo Loayza durante 2014 – 2018 en Lima, Perú [Tesis, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/655343
Rebolledo, K., Asociación entre tiempo de abandono y falla terapéutica en adultos inmigrantes venezolanos con infección por el Virus de Inmunodeficiencia Humana que reinician Terapia Antirretroviral de Gran Actividad atendidos en el Hospital Nacional Arzobispo Loayza durante 2014 – 2018 en Lima, Perú [Tesis]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2021. http://hdl.handle.net/10757/655343
@misc{sunedu/4385379,
title = "Asociación entre tiempo de abandono y falla terapéutica en adultos inmigrantes venezolanos con infección por el Virus de Inmunodeficiencia Humana que reinician Terapia Antirretroviral de Gran Actividad atendidos en el Hospital Nacional Arzobispo Loayza durante 2014 – 2018 en Lima, Perú",
author = "Rebolledo Ponietsky, Kirbeliz Estefania",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2021"
}
Objective: To evaluate the association between antiretroviral treatment interruption with the treatment failure in adults with human immunodeficiency virus (HIV) infection that reinitiates (HAART). Methods: We carried out a retrospective cohort study at the Hospital Nacional Arzobispo Loayza. We included immigrant patients who reinitiate HAART. The outcome was treatment failure (TF) may be immunological (IF), virological (VF), and clinical (CF) failure. The exposure variable was antiretroviral treatment interruption. The control variables measured were sex, sexual orientation, educational level, age, and comorbidities. We performed linear Poisson models with robust standard errors to calculate relative risk at the crude level (RR) and adjusted by statistical and epidemiological criteria. Results: We included 294 in the analysis. 47.7% of them defaulted treatment, 32.7% abandoned less than six months, 15% abandoned more than six months and 27.9% did TF; 24.6% VF; 6.8% IF, and 6.4% CF. A treatment interruption less than 6 months [aRR: 1.98 (95% CI: 1.27 to 3.09);] and from six months to more [aRR: 3.17 (95% CI: 2.02 to 4.95)] increased the risk of TF. Likewise, treatment interruption of up to six months [aRR: 2.85 2.32 (95% CI: 1.40 to 3.84)] and from six months to more [aRR: 3.93 (95% CI: 2.39 to 6,45)]; increased the risk of VF concerning patients who did not abandon treatment. In the CF [aRR: 1,96 (IC95%: 0,67 a 5,79)] and IF [aRR: 2,99 (IC95%: 0,87 a 10,30)] case, we did not find statistical evidence of an association with the abandonment time. Conclusions: The HAART treatment interruption is associated with the development of therapeutic and virologic failure. Treatment interruption should be explored as a variable of high importance in the assessment of patients with HIV.
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