Bibliographic citations
Azañedo, L., Sevilla, E. (2023). Asociación entre la diabetes Mellitus Tipo 2 y la respuesta al tratamiento en pacientes adultos con tuberculosis pulmonar esquema 1 que recibieron atención médica ambulatoria en la región Loreto entre los años 2015 y 2019 [Tesis, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/668399
Azañedo, L., Sevilla, E. Asociación entre la diabetes Mellitus Tipo 2 y la respuesta al tratamiento en pacientes adultos con tuberculosis pulmonar esquema 1 que recibieron atención médica ambulatoria en la región Loreto entre los años 2015 y 2019 [Tesis]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2023. http://hdl.handle.net/10757/668399
@misc{sunedu/3439548,
title = "Asociación entre la diabetes Mellitus Tipo 2 y la respuesta al tratamiento en pacientes adultos con tuberculosis pulmonar esquema 1 que recibieron atención médica ambulatoria en la región Loreto entre los años 2015 y 2019",
author = "Sevilla Acosta, Eduardo ",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2023"
}
Objectives. To evaluate the association between type 2 diabetes mellitus (T2DM) and treatment outcomes in adult patients with pulmonary tuberculosis controlled by sociodemographic and clinical variables. Methods. We carried out a retrospective cohort study including all patients diagnosed with pulmonary tuberculosis in the Loreto region during 2015-2019. The exposure variable was the diagnosis of T2DM. The response variable was defined in two ways: a) polychotomous categorized as treatment failure, deceased, abandonment, and cured, and b) dichotomous: categorized as success and failure. We also measured age, sex, province, HIV infection, alcohol, tobacco and other illicit drug consumption. We applied generalized linear models Poisson family with non-parametric bootstrap with accelerated and corrected bias with 1000 repetitions to estimate crude relative risks (RR) and adjusted by statistical (RRa1) and epidemiological (RRa2) criteria. Additionally, we estimated Relative Risk Ratios (RRR) using multinomial logistic regression models as an exploratory approach. Results. We included 3148 patients, 506 had T2DM (16.1%). The frequency of treatment failure was 11.1% in patients with T2DM compared to 17.0% in those without T2DM (p<0.001). In the regression models, we observed that T2DM decreased the risk of treatment failure at the crude level (RR: 0.65%; 95% CI: 0.50-0.86; p=0.002) and adjusted by statistical criteria (RRa1: 0.68; 95% CI: 0.53-0.89; p=0.005) and epidemiological criteria (RRa2: 0.69; 95% CI: 0.53-0.91; p=0.001). Moreover, the RRR showed no differences in the risk of death between patients with TB and TB-T2DM (RRR: 0.89%; 95% CI 0.57-1.40; p=0.618). However, we found an association between the decrease in the risk ratio of abandonment or failure in patients with TB-T2DM (RRR: 0.50; 95% CI 0.35-0.74; p=<0.001). Conclusions. Patients with type 2 diabetes mellitus have a decreased risk of abandonment and failure of tuberculosis treatment, however, no significant differences were found in the risk of death between the two groups.
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