Bibliographic citations
Vela, C., (2020). Identificación de los polimorfismos de nucleótidos únicos en el exón 8 del gen CYP2D6 en pobladores étnicos de la Comunidad de Tempestad, Loreto [Universidad Nacional de la Amazonía Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6972
Vela, C., Identificación de los polimorfismos de nucleótidos únicos en el exón 8 del gen CYP2D6 en pobladores étnicos de la Comunidad de Tempestad, Loreto []. : Universidad Nacional de la Amazonía Peruana; 2020. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6972
@misc{sunedu/3117984,
title = "Identificación de los polimorfismos de nucleótidos únicos en el exón 8 del gen CYP2D6 en pobladores étnicos de la Comunidad de Tempestad, Loreto",
author = "Vela Luna, Christian",
publisher = "Universidad Nacional de la Amazonía Peruana",
year = "2020"
}
Objective: To determine the single nucleotide polymorphisms in exon 8 of the CYP2D6 gene, in ethnic inhabitants of the Community of Tempestad, Loreto. Methodology: The study was descriptive and cross-sectional in design, the population corresponded to the Quichua ethnic group, with a sample of 32 adult individuals, who previously voluntarily agreed to participate in the study, signing an informed consent; the peripheral blood sample approximately 0.8 mL was supported on filter paper. The isolated chromosomal DNA was analyzed by the QIAGEN method, which was amplified in the region of exon 8 of CYP2D6, identifying the point mutations - SNP. Results: Original allele, (G / C) means: original allele G that changed to C and was identified in 64% (16) of the haplotypes studied and original allele; (C / G) means: original allele C that changed to G and was identified in 24% (6) of the haplotypes studied and 12% (3) that did not present polymorphisms. Conclusions: It is important to highlight that the SNP (G / C) does not show interindividual genetic polymorphism in the population studied, while the SNP (C / G) does represent a genetic polymorphism, however, by themselves they do not determine the detoxification variability of the organism, for the simple fact that these point mutations must first be tested if it affects the amino acid sequence in the genetic expression of the CYP2D6 protein.
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