Bibliographic citations
Ayambo, A., King, C. (2020). Aislamiento e identificación de metabolitos secundarios de las hojas y tallos de Piper amazonicum (Miq.) C. DC., Iquitos, 2018 [Universidad Nacional de la Amazonía Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/7018
Ayambo, A., King, C. Aislamiento e identificación de metabolitos secundarios de las hojas y tallos de Piper amazonicum (Miq.) C. DC., Iquitos, 2018 []. : Universidad Nacional de la Amazonía Peruana; 2020. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/7018
@misc{sunedu/3114693,
title = "Aislamiento e identificación de metabolitos secundarios de las hojas y tallos de Piper amazonicum (Miq.) C. DC., Iquitos, 2018",
author = "King Ramírez, Clairy Darelis",
publisher = "Universidad Nacional de la Amazonía Peruana",
year = "2020"
}
Natural products are an inexhaustible source of secondary metabolites that present a large structural diversity and a variety of bioactive compounds that are used to treat different types of diseases. Species in the Piperaceae family, such as the genus Piper, are a promising source of possible new compounds with important biological activities. Moreover, there are around 3500 species distributed in different parts of the world, and 457 species can be found in Peru, of which 190 are registered in Loreto region. The following research work had the purpose of isolating and identifying the secondary metabolites from leaves and stems of Piper amazonicum (Miq.) C. DC. The dry and ground samples were macerated in hexane and subsequently in dichloromethane; and the solvent was removed by reduced pressure in a rotary evaporator. Using different chromatographic techniques, the dichloromethane extract was then used for the isolation of compounds. The chemical structure of these compounds, was determined by the interpretation of mono-dimensional (1H and 13C) and two-dimensional (COSY, HSQC and HMBC) spectroscopic data; low and high resolution mass spectrometry; and by comparing with the data published in the chemical bibliography for similar compounds. As a result, three (03) chalcone type compounds were isolated and identified: 2',4'-dihydroxy-5'-methyl-6'-methoxychalcone (P-1); 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxy-chalcone (P-2); and 2', 4'- diacetoxy-3', 5'-dimethyl-6'-methoxy-chalcone (P-3).
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