Citas bibligráficas
Espinoza, R., Flores, A. (2021). SARS-CoV-2 y su efecto a nivel de tejido renal: Una revisión narrativa [Trabajo de investigación, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/659445
Espinoza, R., Flores, A. SARS-CoV-2 y su efecto a nivel de tejido renal: Una revisión narrativa [Trabajo de investigación]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2021. http://hdl.handle.net/10757/659445
@misc{sunedu/3107875,
title = "SARS-CoV-2 y su efecto a nivel de tejido renal: Una revisión narrativa",
author = "Flores Gavino, Aldo Paul",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2021"
}
We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin–Angiotensin–Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.
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