Bibliographic citations
Rafael, Y., (2024). Efecto del extracto acuoso liofilizado de Trifolium pratense L. sobre depresión inducida en Rattus norvegicus Holtzman [Universidad Nacional de Trujillo]. https://hdl.handle.net/20.500.14414/22446
Rafael, Y., Efecto del extracto acuoso liofilizado de Trifolium pratense L. sobre depresión inducida en Rattus norvegicus Holtzman []. PE: Universidad Nacional de Trujillo; 2024. https://hdl.handle.net/20.500.14414/22446
@misc{renati/884229,
title = "Efecto del extracto acuoso liofilizado de Trifolium pratense L. sobre depresión inducida en Rattus norvegicus Holtzman",
author = "Rafael Manosalva, Yasseli Jhomara",
publisher = "Universidad Nacional de Trujillo",
year = "2024"
}
ABSTRACT The aim of this study was to determine the effect of Trifolium pratense L. on the parameters of horizontal swimming (serotonergic activation), vertical swimming (noradrenergic activation) and immobility according to the Porsolt test in Rattus norvegicus Holtzman. The sample of Trifolium pratense L., collected from the district of Chota, province of Chota, Cajamarca region, Peru, was pre-frozen at -80 °C and then taken to the freeze-drying process. Twenty-four female specimens of Rattus norvegicus Holtzman were used, distributed in four groups, control (distilled water), standard (fluoxetine 20 mg/kg) and two problem groups (freeze-dried aqueous extract of Trifolium pratense L. at 250 mg/kg and 500 mg/kg), for 28 days. The modified forced swim test method (modified Porsolt test) was used to determine the antidepressant activity. The variables assessed were vertical swim, horizontal swim and immobility for 5 minutes on day 28 of treatment. Data were analysed using ANOVA and Bonferroni's test as a post hoc test. The results showed that the doses of 250 and 500 mg/kg of the freeze-dried aqueous extract of Trifolium pratense L. in horizontal swimming (swimming) presented an antidepressant effect statistically similar (p > 0.05) to the standard (fluoxetine) indicating serotonergic activation, and in the immobility parameter a decreasing effect was generated (p < 0.001), evidencing as such the expected antidepressant effect.
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