Citas bibligráficas
Millonig, R., Vargas, E. (2024). Efecto del bioisóstero Q7Cl del paracetamol sobre la nocicepción en Rattus norvegicus var. Holtzman [Universidad Nacional de Trujillo]. https://hdl.handle.net/20.500.14414/22486
Millonig, R., Vargas, E. Efecto del bioisóstero Q7Cl del paracetamol sobre la nocicepción en Rattus norvegicus var. Holtzman []. PE: Universidad Nacional de Trujillo; 2024. https://hdl.handle.net/20.500.14414/22486
@misc{renati/882509,
title = "Efecto del bioisóstero Q7Cl del paracetamol sobre la nocicepción en Rattus norvegicus var. Holtzman",
author = "Vargas Lezama, Elizabeth",
publisher = "Universidad Nacional de Trujillo",
year = "2024"
}
ABSTRACT The research aim is evaluate the effect of the Q7Cl bioisostere of paracetamol on nociception in Rattus norvegicus var. Holtzman. For this purpose, 20 Rattus norvegicus var. Holtzman were acquired and assigned into 4 groups of 5 specimens each; control group, standard, problem 1, and problem 2, were administered orally by 1 mL syringes; 0.5 mL of tween 80, 12.5 mg/kg bw of paracetamol; 12.5 mg/kg bw of Q7Cl bioisostere and 25 mg/kg bw of Q7Cl bioisostere, respectively. Subsequently, they were introduced into the hot plate equipment at a temperature of 55°C, to measure the response time to the term stimulus by paw licking or jumping, the times to be evaluated were 30, 60, 120, 180, 240, and 300 minutes. After the seven-day depuration period, the same procedure was followed for the cold plate method, with the difference that the thermal stimulus was 5°C. The data obtained were evaluated by analysis of variance (ANOVA) with the statistical program GraphPad Prism version 8.0.2, and when a significant difference was found, the complementary test, Tukey's test, was applied. In the hot plate, bioisostere Q7Cl at a dose of 12.5 mg/kg showed slightly better antinociceptive effect as paracetamol (p>0.05) but increased antinociceptive effect statistically significant in comparison with tween 80 (p<0.001) and increased antinociceptive effect statistically significant in comparison with the dose of 25mg/kg (p<0.05). In the cold plate, Q7Cl bioisostere at the dose of 12.5 mg/kg and 25 mg/kg demonstrated increased statistically significant antinociceptive effects (p<0.01) compared to tween 80 and increased antinociceptive effects compared to paracetamol (p>0.05). In conclusion, bioisostere Q7Cl at both doses (12.5 mg/kg and 25 mg/kg) showed antinociceptive effect on Rattus norvegicus var. Holtzman in hot plate (55 °C) and cold plate (5° C) test.
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