Citas bibligráficas
Quiroz, D., (2020). Estudio de estabilidad de carboplatino 150 mg polvo liofilizado para solución inyectable mediante degradación forzada [Tesis, Pontificia Universidad Católica del Perú]. http://hdl.handle.net/20.500.12404/16852
Quiroz, D., Estudio de estabilidad de carboplatino 150 mg polvo liofilizado para solución inyectable mediante degradación forzada [Tesis]. PE: Pontificia Universidad Católica del Perú; 2020. http://hdl.handle.net/20.500.12404/16852
@mastersthesis{renati/528213,
title = "Estudio de estabilidad de carboplatino 150 mg polvo liofilizado para solución inyectable mediante degradación forzada",
author = "Quiroz Delgado, Deivy",
publisher = "Pontificia Universidad Católica del Perú",
year = "2020"
}
Cancer is a serious health problem worldwide and Peru is not free from this reality. Within this global picture there is a wide variety of malignant tumors for which different antineoplastic drugs are used. Among the most used in the different systems of health are included the platinum derivatives: cisplatin and carboplatin. Carboplatin (cis-1,1- diamine cyclobutanedicarboxylate platinum II) is an analogue of cisplatin (cisdiaminodichloroplatinum II), but carboplatin, unlike cisplatin, does not cause renal or neurological toxicity, which is why it is mainly used in hospitals for parenteral administration by intravenous infusion. The mechanism of molecular action is not completely understood, it is believed that carboplatin exerts its biological effects through interaction with target cells. In the present work, the study of the stability of six formulations of carboplatin 150 mg lyophilized powder for solution for injection was carried out using the method of forced degradation, considering the variables temperature and time. The samples were subjected to four conditions of forced degradation; later they were analyzed and compared with the results obtained from the samples that were not submitted to any forced degradation condition. The analytical methods used were: Karl Fisher to determine the amount of water present in the formulations, the electroanalytical technique potentiometry to determine the pH of each formulation, high performance liquid chromatography (HPLC) to determine the variations with respect to the dosage and impurity limits of each of the formulations and nuclear magnetic resonance of the proton (1H-NMR) and carbon (13C-NMR) to determine the main excipients of each formulation.
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