Citas bibligráficas
Rojas, M., (2024). Eficacia del tratamiento con minociclina tópica en rosácea papulopustular: Revisión sistemática y Metaanálisis [Tesis, Universidad Privada Antenor Orrego]. https://hdl.handle.net/20.500.12759/38811
Rojas, M., Eficacia del tratamiento con minociclina tópica en rosácea papulopustular: Revisión sistemática y Metaanálisis [Tesis]. PE: Universidad Privada Antenor Orrego; 2024. https://hdl.handle.net/20.500.12759/38811
@misc{renati/499709,
title = "Eficacia del tratamiento con minociclina tópica en rosácea papulopustular: Revisión sistemática y Metaanálisis",
author = "Rojas Silva, Mauricio",
publisher = "Universidad Privada Antenor Orrego",
year = "2024"
}
Objective: Determine the efficacy of topical minocycline in patients with papulopustular rosacea. Material and methods: The present study was governed by the PRISMA 2020 guidelines. The search expression was carried out in various databases such as Pubmed, web of sciences, EMBASE, SCOPUS, Cochrane and Google academic. Clinical trials were included, which were filtered and stored using the Rayyan platform. Data collection was carried out using Microsoft Excel 2019. The risk of bias was assessed through the Cochrane Collaboration's RoB 2.0 tool. For the meta-analysis, the statistical analysis was performed using Cochrane's RevMan web software. The quality and certainty of the evidence were evaluated using the GRADEpro program Results: For the meta-analysis, 6 different studies from 3 selected randomized clinical trials were evaluated. After 12 weeks of treatment, a significant difference was observed in favor of topical minocycline both in the reduction to scores 0-1 on the IGA scale (RR: 1.33 [1.15,1.53], 95% CI, I2:21%, Z = 3.91 (P < 0.0001)) as in the decrease in the count of inflammatory lesions (RR: 1.68 [1.26,2.25], 95% CI, I2:23%, Z= 3.48 (P < 0.0005)) in comparison with placebo. Conclusion: Topical minocycline demonstrated a notable reduction in both lesion count and the Investigator's Global Assessment (IGA) score when compared to the placebo
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