Bibliographic citations
Cori, M., Cortez, A. (2024). Factores asociados al desarrollo de injuria renal aguda en pacientes hospitalizados por COVID-19 en dos hospitales públicos en Lima, Perú [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/15540
Cori, M., Cortez, A. Factores asociados al desarrollo de injuria renal aguda en pacientes hospitalizados por COVID-19 en dos hospitales públicos en Lima, Perú []. PE: Universidad Peruana Cayetano Heredia; 2024. https://hdl.handle.net/20.500.12866/15540
@misc{renati/494143,
title = "Factores asociados al desarrollo de injuria renal aguda en pacientes hospitalizados por COVID-19 en dos hospitales públicos en Lima, Perú",
author = "Cortez Velazco, Angie Katherine",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2024"
}
Introduction: SARS-CoV-2 infection was declared a pandemic by the WHO in 2020. Factors associated with the development of Acute Kidney Injury (AKI) in COVID-19 patients have been described, such as age, male sex, obesity and mechanical ventilation. Objectives: To evaluate if the following variables constitute factors associated with the appearance of AKI: age over 60 years, male sex, hypertension (HTA), Diabetes Mellitus (DM), obesity, nephrotoxic drugs, lymphopenia, inflammatory markers (Ferritin, LDH, CRP, D-dimer), hypoxemic respiratory failure and VMI. Materials and methods: This is a case-control design, with prevalent cases. The data were obtained from the medical records of adult patients hospitalized with COVID-19 at the Cayetano Heredia Hospital and the Arzobispo Loayza National Hospital during January to March 2021. The cases are patients with COVID-19, with a diagnosis of AKI, and the controls, those with COVID-19 without AKI. Results: 211 cases and 211 controls were evaluated. The cases were mostly hospitalized in the emergency department (20.9% vs 10.0%) and in the intensive care unit (29.4% vs 24.6%) (p = 0.001) and the mortality rate was higher in patients with AKI (49.3% vs 33.25) . p= 0.002). In the bivariate analysis, the presence of HTA, Obesity, DM, higher levels of CRP, ferritin, presence of lymphopenia, lower levels of PaO2 and exposure to nephrotoxic drugs were associated with the presence of AKI. In the multivariate analysis, only the condition of being HTA was considered [ORa: 3.78 (2.35 – 6.20); p = 0.001]; being diabetic [ORa: 2.06 (1.17 – 3.71); p = 0.014] and the use of nephrotoxic drugs [ORa: 3.12 (1.92 – 5.14); p = 0.001] were independently associated with the occurrence of AKI: only the presence of lymphopenia [ORa: 0.51 (0.32 – 0.81); p = 0.004], constituted a protective factor for the appearance of AKI in patients infected with COVID-19. Conclusion: Having HTA, DM and the use of nephrotoxic drugs were associated with the occurrence of AKI in patients infected with Covid-19.
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