Bibliographic citations
Rondon, D., (2021). Diferencias metabolómicas del cáncer colorrectal y pólipos colorrectales por género reveladas mediante análisis bioinformático [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/9715
Rondon, D., Diferencias metabolómicas del cáncer colorrectal y pólipos colorrectales por género reveladas mediante análisis bioinformático []. PE: Universidad Peruana Cayetano Heredia; 2021. https://hdl.handle.net/20.500.12866/9715
@mastersthesis{renati/493824,
title = "Diferencias metabolómicas del cáncer colorrectal y pólipos colorrectales por género reveladas mediante análisis bioinformático",
author = "Rondon Soto, Diego",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2021"
}
Introduction: Colorectal cancer (CRC) is the third type of cancer in incidence and the second in mortality globally, both are higher in men. This disease has been treated equally in both genders. However, multiple studies reveal that the prognosis, pharmacology, and risk of recurrence of CRC vary depending on gender. Objective: To distinguish the metabolomic profile of men and women with colorectal polyps and CRC through a secondary analysis of metabolomic data obtained by LC-MS. Methods: The study is descriptive and retrospective cross-sectional. Results: A total of 32 and 11 different metabolites were obtained between men and women with colorectal polyps and CRC, respectively. Glycine and valine (p = 0.0002 and p = 0.0003, respectively) showed the most significant differences in patients with polyps and acetyl choline, creatinine and pyroglutamic acid (p <0.05, p <0.05 and p = 0.0001, respectively) in individuals with CCR. The metabolic pathways associated with colorectal polyps were the aminaoacil t-RNA synthesis pathway (p <0.05) and the glycine, serine, and threonine pathway (p = 0.003); and to CCR were the routes of ubiquinone and other terpenoids (p = 0.04) and the synthesis of vitamin B6 (p = 0.04). Conclusions: It was possible to distinguish the metabolomic profile between genders for the three groups (healthy, polyps and CRC), finding metabolites with significantly different abundances and different metabolic pathways altered by gender.
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