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Valenzuela, G., (2004). Tuberculosis en pacientes con lupus eritematoso sistématico : estudio caso control [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/2934
Valenzuela, G., Tuberculosis en pacientes con lupus eritematoso sistématico : estudio caso control [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2004. https://hdl.handle.net/20.500.12672/2934
@phdthesis{renati/489635,
title = "Tuberculosis en pacientes con lupus eritematoso sistématico : estudio caso control",
author = "Valenzuela Rodríguez, Germán Víctor",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2004"
}
Título: Tuberculosis en pacientes con lupus eritematoso sistématico : estudio caso control
Autor(es): Valenzuela Rodríguez, Germán Víctor
Asesor(es): Acevedo Vásquez, Eduardo Manuel
Palabras clave: Lupus eritematoso sistémico - Diagnóstico; Tuberculosis - Complicaciones
Campo OCDE: https://purl.org/pe-repo/ocde/ford#3.00.00
Fecha de publicación: 2004
Institución: Universidad Nacional Mayor de San Marcos
Resumen: Con el objetivo de evaluar las características clínicoepidemiológicas de la Tuberculosis (TB) en pacientes con Lupus Eritematoso Sistémico (LES), diseñamos un estudio casocontrol en el Servicio de Reumatología del Hospital Nacional Guillermo Almenara frigoven. Para tal fin, evaluamos los registros clínicos de 387 pacientes con LES atendidos entre los años 1990 y 2002.
Durante este lapso encontramos 14 casos de Tuberculosis (TB) apareados con 28 controles con LES sin TB según sexo y edad. Los pacientes con TB tuvieron un mayor tiempo de enfermedad y recibieron una mayor dosis acumulada de corticoides. No encontramos diferencias entre la presentación clínica de LES entre ambos grupos.
Siete casos (50%) correspondieron a pacientes con TB extrapulmonar. Respectivamente fueron 1 caso de TB osteoarticular, meníngea, pleural, endobronquial, renal, pericárdica y cutánea. Los pacientes con TB pulmonar tuvieron un mayor tiempo de LES y los pacientes con TB extrapulmonar una mayor frecuencia de antecedentes de TB.
El diagnóstico de TB fue hecho por la búsqueda de bacilos ácidoalcohol resistentes (BAAR) en 617 casos de TB pulmonar y 417 casos de TB extrapulmonar.
Conclusión: Encontramos 14 casos (3.61%) de TB en pacientes con LES. 50% correspondieron a formas extrapulmonares. Los pacientes con TB tuvieron un mayor tiempo de LES y recibieron una mayor dosis de corticoides. Recomendamos el diagnóstico precoz de TB en pacientes con LES ofreciendo profilaxis antituberculosa con Isoniazida a todos los pacientes.
To evaluate the clinical and epidemiological characteristics of TB in patients with SLE, we design a casecontrol study in the Rheumatology service of the Hospital Nacional Guillermo Almenara. For this purpose, we reviewed the clinical charts of 387 patients with SLE who were hospitalized between 1990 and 2002. During this time we found 14 cases of TB matched wíth 28 patients with LES but without TB according to sex and age. Patients with TB had a higher time of SLE and received a higher accumulate dosis of steroidá. We did not found differences between the clinical presentation of SLE of thís groups. Seven cases (50%) correspond to patients with extrapulmonary TB. Respectively were included cases of osteoarticular, meningeal, pleural, endobronchíal, renal, pericardical and cutaneous TB. People with pulmonary TB had a higher time of SLE and patients with extrapulmonary TB had a higher frequency of TB history. The diagnoses of TB were made by study of acid fast bacilli in 617 cases of pulmonary TB and 417 cases of extrapulmonary TB. Conclusion: We found 14 cases (3.61 %) of TB in SLE patients. 50% correspond to extrapulmonary forms. Patients with TB had a higher time of SLE and received a higher dosage of steroids. We recommend strategies for an early diagnoses of TB in SLE patients and Isoniazid usage in all of them.
To evaluate the clinical and epidemiological characteristics of TB in patients with SLE, we design a casecontrol study in the Rheumatology service of the Hospital Nacional Guillermo Almenara. For this purpose, we reviewed the clinical charts of 387 patients with SLE who were hospitalized between 1990 and 2002. During this time we found 14 cases of TB matched wíth 28 patients with LES but without TB according to sex and age. Patients with TB had a higher time of SLE and received a higher accumulate dosis of steroidá. We did not found differences between the clinical presentation of SLE of thís groups. Seven cases (50%) correspond to patients with extrapulmonary TB. Respectively were included cases of osteoarticular, meningeal, pleural, endobronchíal, renal, pericardical and cutaneous TB. People with pulmonary TB had a higher time of SLE and patients with extrapulmonary TB had a higher frequency of TB history. The diagnoses of TB were made by study of acid fast bacilli in 617 cases of pulmonary TB and 417 cases of extrapulmonary TB. Conclusion: We found 14 cases (3.61 %) of TB in SLE patients. 50% correspond to extrapulmonary forms. Patients with TB had a higher time of SLE and received a higher dosage of steroids. We recommend strategies for an early diagnoses of TB in SLE patients and Isoniazid usage in all of them.
Enlace al repositorio: https://hdl.handle.net/20.500.12672/2934
Disciplina académico-profesional: Medicina
Institución que otorga el grado o título: Universidad Nacional Mayor de San Marcos. Facultad de Medicina. Unidad de Posgrado
Grado o título: Doctor en Medicina
Fecha de registro: 20-ago-2013
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