Citas bibligráficas
Gonzales, J., (2010). Evaluación de la expresión de Ccna1, Cyp17, StAR y Prm2 en la espermatogénesis de ratones Swiss Rockefeller tratados con Lepidium meyenii Walp. (maca) [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/969
Gonzales, J., Evaluación de la expresión de Ccna1, Cyp17, StAR y Prm2 en la espermatogénesis de ratones Swiss Rockefeller tratados con Lepidium meyenii Walp. (maca) [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2010. https://hdl.handle.net/20.500.12672/969
@misc{renati/484928,
title = "Evaluación de la expresión de Ccna1, Cyp17, StAR y Prm2 en la espermatogénesis de ratones Swiss Rockefeller tratados con Lepidium meyenii Walp. (maca)",
author = "Gonzales Daga, José Manuel",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2010"
}
Lepidium meyenii Walp. (maca) (Brassicaceae) is widely used as a folk medicine, for the ability to enhance the sexual performance in humans, rats and mice, besides to improve the spermatogenesis. However, the way maca acts on spermatogenesis still unclear. In this study, adult male mice were treated with maca aqueous extract during periods of 7, 14 and 21 days, after each treatment, physiological parameters were measured and the expression of cyclin A1 (Ccna1), cytochrome P450 17α-hydroxylase/17,20-lyase (Cyp17), protamine 2 (Prm2) and steroidogenic acute regulatory protein (StAR) (genes involved in spermatogenesis), were recorded. The results shows that maca increased significantly (p less than 0.05) sperm concentration in the three treatment groups, plus Ccna1, CYP17 and Prm2 expression were not significantly affected, while StAR, shows a negative regulation on their expression in groups of 7 and 14 days of treatment. These results suggest, that the mechanism maca increases sperm concentration is not related to increased meiotic activity, or the synthesis of testosterone, but rather the response of a component with androgenic activity present in the aqueous extract of maca, evidenced by the negative effect on StAR expression. These results re-enact the importance of maca as reproductive enhancer without running the risk of increased androgen contraindicated in cases of prostate cancer.
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