Citas bibligráficas
Chirinos, L., (2004). Efecto de la capreomicina sobre la función renal en pacientes con tuberculosis multidrogoresistente pulmonar [Tesis de segunda especialidad, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/1809
Chirinos, L., Efecto de la capreomicina sobre la función renal en pacientes con tuberculosis multidrogoresistente pulmonar [Tesis de segunda especialidad]. PE: Universidad Nacional Mayor de San Marcos; 2004. https://hdl.handle.net/20.500.12672/1809
@misc{renati/474129,
title = "Efecto de la capreomicina sobre la función renal en pacientes con tuberculosis multidrogoresistente pulmonar",
author = "Chirinos Zegarra, Luis Hernando",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2004"
}
--- Objective: To determine the effect of Capreomycin in the purification of calculated Creatinine in patients with a diagnose of “Multidrugresistant Tuberculosis”. To determine the epidemic profile; the frequency of use of Capreomycin; if deterioration of purification of calculated Creatinine exists; the use of AntiTBC drugs such as therapy associated with Capreomycin and to establish the condition of discharged patients with “Multidrugresistant Tuberculosis”. Method: A retrospective descriptive study was carried out in patients with “Multidrugreststant Tuberculosis,” that were treated in the Pneumonia Unit of the “HNGAI” between 2000-2002 and who received the Drug Capreomycin as a complementary individualized treatment., 358 Clinical Histories were checked of patients, that received individualized treatment between 2000 and 2002 inclusive; of those, 105 patients received Capreomycin, 100 patients fulfilled the inclusion approaches, which is the total sample Results 62% of patients were men, 70% were aged between 15 and 45 years old, 59% had secondary education, 79% of patients came out cured, the average treatment time for Capreomycin was of 18.42 months, 59% of the sample received treatment for between 12 and 24 months, 15% received treatment from 24 to 42 months, the associated drugs used with more frequency were Capreomycin (100%), Cycloserine(100%) Amoxicillin/Clavulanic Acid (94%) Ofloxacine(71%) Pyrazinamide(60%) with an average of 4.94 drugs, 73% of patients received doses of between 150 to 350 grams of Capreomycin in total , with an average dose of 273.73 grams. The study of sensibility of stumps demonstrated Resistance to First Line Drugs in 96%, 94%, 68%, 76% in Rifampin, Isoniacid, Pyrazinamide and Streptomycin respectively, it demonstrated Sensitivity to Thioacetazona (33%), Kanamycina (41%), Pyrazinamide (28%) and PAS (29%). In the first Control: 51% of the series had more than the 90% of Calculated Purification Cretinine (Normal), 41% of the same series had light damage, that is to say between 60 to 89% of Purification; 8% had Moderate damage, none with Renal failure or Severe damage; with averages values of the whole series of Creatinina Sérica of 79.49 rngs, and with an average of 92.18% Purification of Calculated Creatinina and an average weight of 61.03 Kgs. In the second control of Purification of Calculated Creatinina, in general 18 months into the treatment with Capreomycin, 51% persists with normal values, 41% with light damage; and it was noted that 7% was moderately damaged (Purification between 30 to 59%) and 1% with Severe Damage (Purification between 15 to 29%), the average value of Creatinina Sérica is 82.15mgs, with a calculated Purification average of 90.48% and a weight of 62.36 Kgs. In the studied series it was observed that 16 lobectomias and 5 neumonectomias were carried out in the patients. CONCLUSION: Capreomycin doesn't demonstrate great ,nor in the Calculated Purification of Creatinine; using the Equation of Cockcroft-Gault; with high dose and a prolonged time of administration of the drug; being tolerated by the TBC-MDR patient.
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