Citas bibligráficas
Avalos, M., (2022). Exposición prenatal a antibióticos como factor de riesgo para enterocolitis necrotizante en recién nacidos prematuros [Tesis, Universidad Privada Antenor Orrego - UPAO]. https://hdl.handle.net/20.500.12759/9740
Avalos, M., Exposición prenatal a antibióticos como factor de riesgo para enterocolitis necrotizante en recién nacidos prematuros [Tesis]. PE: Universidad Privada Antenor Orrego - UPAO; 2022. https://hdl.handle.net/20.500.12759/9740
@misc{renati/374435,
title = "Exposición prenatal a antibióticos como factor de riesgo para enterocolitis necrotizante en recién nacidos prematuros",
author = "Avalos Rodríguez, Mónica de los Ángeles",
publisher = "Universidad Privada Antenor Orrego - UPAO",
year = "2022"
}
To analyze whether prenatal exposure to antibiotics is a risk factor for necrotizing enterocolitis (NEC) in premature newborns (NBs). Method: Case control study, where the medical records of 216 premature newborns and their mothers, born at the Hospital Regional Docente de Trujillo and Hospital Belén de Trujillo between 2014 and 2019, divided into 72 newborns with NEC and 144 controls, were examined. The exposure to corticosteroids and antibiotics before delivery was verified in the mothers, in the latter the time of administration was recorded according to the nursing kardex. Frequencies, odds ratio (OR), and adjusted OR were determined by multivariate analysis. Results: 58.3% of the newborns with NEC and 51.4% of the controls were exposed to prenatal antibiotics (p=0.335). Exposure to aminoglycoside was associated with NEC, although it did not remain significant in the multivariate. The initiation of antibiotics between 48 and 72 hours before delivery was more frequent in NBs with NEC (16.7%) and remained an independent risk factor in the multivariate analysis (aOR: 2.63, 95% CI: 1.7-7.11). The intervening risk factors were prenatal corticosteroid therapy (aOR: 2.06, 95% CI: 1.11-3.83) and late sepsis (aOR: 2.29, 95% CI: 1.15-4.59). Conclusion: Prenatal exposure to antibiotics is a risk factor for necrotizing enterocolitis in preterm infants.
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