Bibliographic citations
Zavalaga, H., Palomino, J. (2022). C-Reactive Protein-to-albumin ratio and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis [Tesis, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/667632
Zavalaga, H., Palomino, J. C-Reactive Protein-to-albumin ratio and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis [Tesis]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2022. http://hdl.handle.net/10757/667632
@misc{renati/1294037,
title = "C-Reactive Protein-to-albumin ratio and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis",
author = "Palomino Gutiérrez, Juan Jose",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2022"
}
C-reactive protein-to-albumin ratio (CAR) is an independent risk factor in cardiovascular, cerebrovascular, and infectious diseases. The main objective of this study was to see if CAR can be used as a predictor of severity or mortality in people who developed disease caused by COVID-19. We performed a systematic review and meta-analysis to retrieve studies that evaluated CAR values upon hospital admission in relation to the severity or mortality of COVID-19 patients. We adopted a random-effect model to calculate the pooled mean difference (MD) and their 95% confidence intervals (CI). Quality assessment was appraised using a Newcastle–Ottawa scale and publication bias was assessed using the Begg-test and funnel plot. We equally performed a subgroup analysis using study location and a sensitivity analysis only with studies with low risk of bias. We analyzed 32 studies (n = 12445). Severe COVID-19 patients had higher on-admission CAR values than non-severe COVID-19 patients (MD: 1.69; 95% CI: 1.35–2.03; p < 0.001; I2 = 89%). Non-survivor patients with COVID-19 had higher CAR values than survivor patients (MD: 2.59; 95% CI: 1.95–3.23; p < 0.001; I2 = 92%). In sensitivity analysis, the relationship remained with a decreasing of heterogeneity for severity (MD: 1.22; 95% CI: 1.03–1.40; p < 0.001; I2 = 13%) and for mortality (MD: 2.99; 95% CI: 2.47–3.51; p < 0.001; I2 = 0%). High CAR values were found in COVID-19 patients who developed severe disease or died.
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