Citas bibligráficas
Vargas, C., (2024). “Mecanismos de respuesta inmunológica frente al virus de la rabia y perspectivas de inmunoprevención en reservorios silvestres” [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/16568
Vargas, C., “Mecanismos de respuesta inmunológica frente al virus de la rabia y perspectivas de inmunoprevención en reservorios silvestres” []. PE: Universidad Peruana Cayetano Heredia; 2024. https://hdl.handle.net/20.500.12866/16568
@mastersthesis{renati/1281962,
title = "“Mecanismos de respuesta inmunológica frente al virus de la rabia y perspectivas de inmunoprevención en reservorios silvestres”",
author = "Vargas Tacuri, Cesar Augusto",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2024"
}
The aim of this review was to systematically synthesize the articles related to the immune response against the rabies virus, the evasion mechanisms used by it, and to review the perspectives of anti-rabies vaccination in wildlife. The review was carried out using the PUBMED, SCIENCE DIRECT and EUROPE PMC databases. Fifty-three studies published between 2004 and 2024 report immune response mechanisms against the rabies virus in animal models. The innate immune response is represented mainly by the function of TLR4 and TLR7, as well as the upregulation of IFIT3, IFIT2, IIGP1, TNF – α, RIG – I and NLRP3. The adaptive immune response is represented only by infiltration of B cells, dendritic cells and resident memory T lymphocytes. The most notable immune evasion mechanisms are the antagonism of IFN-γ by blocking the NF-κB and JAK-STAT pathways through the interaction of viral proteins. On the other hand, eight articles published in the last 20 years report data on the application of oral vaccines in wildlife in various countries as well as the results obtained. The case of Serbia and its oral vaccine in foxes demonstrated high efficiency in the control and prevention of rabies. Currently, the objective is to immunize bat populations with oronasal, topical and self-disseminated vaccines with the advances of genetic engineering and immunoproteomics. More studies of immunoprevention in wildlife are required under a “one health” approach.
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons