Citas bibligráficas
Espinoza, R., (2024). “Caracterización fenotípica y funcional de las células T invariantes asociadas a mucosa (MAIT) en las neoplasias colorrectales” [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/16507
Espinoza, R., “Caracterización fenotípica y funcional de las células T invariantes asociadas a mucosa (MAIT) en las neoplasias colorrectales” []. PE: Universidad Peruana Cayetano Heredia; 2024. https://hdl.handle.net/20.500.12866/16507
@mastersthesis{renati/1281940,
title = "“Caracterización fenotípica y funcional de las células T invariantes asociadas a mucosa (MAIT) en las neoplasias colorrectales”",
author = "Espinoza Anchaygua, Ricardo Daniel",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2024"
}
Mucosal-associated invariant T cells (MAIT) are a subgroup of unconventional T cells, which exhibit features of both the innate and adaptive immune systems. These lymphocytes are characterized by their mucosal distribution, their multiple mechanisms of activation, their dual capacity to polarize to a Th1 and Th17 phenotype, and a potent cytotoxic capacity. In colorectal cancer, an increased frequency of MAIT cells in tumor tissue has been identified, which is correlated with adverse clinical outcomes. Chronic inflammation and damage of the epithelial barrier of the intestinal mucosa results in the release of antigens and inflammatory mediators, which could activate MAIT cells and exert their effector mechanisms in the tumor microenviroment. The aim of this scoping review is to describe the phenotypic and functional characteristics of MAIT cells in colorectal neoplasms. A literature search was performed in the MEDLINE database. We also described the potential implications of MAIT cell functional alterations in tumor immunology.
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