Bibliographic citations
Moreno, J., Osorio, E. (2024). Efecto hepatoprotector del extracto etanólico de las hojas de desmodium molliculum (MANAYUPA) en Rattus rattus [Universidad María Auxiliadora]. https://hdl.handle.net/20.500.12970/2323
Moreno, J., Osorio, E. Efecto hepatoprotector del extracto etanólico de las hojas de desmodium molliculum (MANAYUPA) en Rattus rattus []. PE: Universidad María Auxiliadora; 2024. https://hdl.handle.net/20.500.12970/2323
@misc{renati/1112310,
title = "Efecto hepatoprotector del extracto etanólico de las hojas de desmodium molliculum (MANAYUPA) en Rattus rattus",
author = "Osorio Bayona, Esperanza Diana",
publisher = "Universidad María Auxiliadora",
year = "2024"
}
Objective: to determine the hepatoprotective effect of the ethanolic extract of the leaves of Desmodium molliculum (manayupa) in Rattus rattus. Material and method: the research was explanatory and experimental in design, 30 albino rats were used distributed in five groups (n=6), the liver damage was induced with 400 mg/kg of paracetamol, the groups (G) received: G1 physiological serum 4 mL/Kg, G2 silymarin 15 mg/kg, G3, G4 and G5 extract in doses of 50, 100 and 200 mg/kg respectively, the hepatic macroscopic and the hepatic profile were evaluated. Results: the percentage yield of the manayupa extract was 8.3%, and it presented alkaloids, flavonoids, phenolic compounds, tannins and triterpene steroids. The greatest hepatoprotective effect was shown by the extract at 200 mg/kg of the extract, maintaining the hepatic profile within normal blood levels. Macroscopic evaluation of the livers showed normal weight and color. Silymarin was shown to be slightly more effective than the extract at a dose of 200 mg/kg. Conclusions: it was concluded that the ethanolic extract of the leaves of Desmodium molliculum (manayupa) has a hepatoprotective effect on Rattus rattus, with induction of liver damage by paracetamol.
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