Bibliographic citations
Gomez, A., (2021). Estudio de la relación de la actividad enzimática de la pepsina en la disolución de cápsulas de gelatina con crosslinking [Universidad Nacional de Trujillo]. https://hdl.handle.net/20.500.14414/18979
Gomez, A., Estudio de la relación de la actividad enzimática de la pepsina en la disolución de cápsulas de gelatina con crosslinking []. PE: Universidad Nacional de Trujillo; 2021. https://hdl.handle.net/20.500.14414/18979
@misc{renati/1050853,
title = "Estudio de la relación de la actividad enzimática de la pepsina en la disolución de cápsulas de gelatina con crosslinking",
author = "Gomez Alva, Arnold Manuel",
publisher = "Universidad Nacional de Trujillo",
year = "2021"
}
ABSTRACT The objective of the present report was to study the relationship of the enzymatic activity of pepsin in the solution of crosslinking capsules. Initially, crosslinking induction was performed using an aqueous formaldehyde solution (10%), in two different ways: exposure to vapors and direct contact with the solution. After that procedure, the thermal analysis was carried out in order to obtain the thermal events corresponding to the gelatin and formaldehyde. After verifying the induction of the crosslinking, the capsules were filled with a formulation containing carvedilol (12.5%), lactose (86.5%) and magnesium stearate (1%). From this, the dissolution of the capsules was carried out following the experimental designs: the first, with the evaluation of the enzymatic activity of the pepsin on the two types of crosslinking induction and the second, for verification of the enzymatic activity of a same method of induction of crosslinking, with different exposure times of 6, 12 and 24 hours. According to the results presented, it was found that the immersion of the capsules in the formaldehyde solution generated a very intense crosslinking, not having a break in the envelope and release of its contents, showing the limitation of the enzyme. On the contrary, for the lowest levels of crosslinking, both the presence and the amount of enzyme in the dissolution medium are fundamental, allied to the pH of the medium that should be the one with the highest activities for the enzyme
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