Citas bibligráficas
Silva, C., (2022). Efecto del extracto de Ipomoea batatas sobre el desarrollo tumoral en Rattus norvegicus var. albinus con cáncer de mama inducido [Universidad Nacional de Trujillo]. https://hdl.handle.net/20.500.14414/20446
Silva, C., Efecto del extracto de Ipomoea batatas sobre el desarrollo tumoral en Rattus norvegicus var. albinus con cáncer de mama inducido []. PE: Universidad Nacional de Trujillo; 2022. https://hdl.handle.net/20.500.14414/20446
@phdthesis{renati/1048035,
title = "Efecto del extracto de Ipomoea batatas sobre el desarrollo tumoral en Rattus norvegicus var. albinus con cáncer de mama inducido",
author = "Silva Correa, Carmen Rosa",
publisher = "Universidad Nacional de Trujillo",
year = "2022"
}
The purpose of this study was to evaluate the effect of the ethanolic extract of Ipomoea batatas on induced breast cancer in rats. For this, the ethanolic extract was prepared using the husks of the roots of I. batatas, leaving them to macerate in 96° ethanol acidified to pH 3.5. Four experimental groups were divided: DMBA Control Group: made up of 10 Rattus norvegicus var. albinus, females, who received 7,12-dimethylbenzo (α) anthracene (DMBA) in a single dose of 20 mg subcutaneously and physiological saline solution orally for 4 months, Problem groups I, II and III: Each one made up of 10 Rattus norvegicus var. albinus, females, who received a single dose of DMBA and 200, 400 and 600 mg/kg/day orally of the I. batatas extract, respectively, for 4 months. The specimens were evaluated weekly by palpation at the level of the thoracoabdominal wall and the inguinal region, to detect the presence of tumors and record the time of appearance of mammary tumors (latency), after which, the animals were euthanized by an overdose of pentobarbital, proceeding to extract the tumors to determine the volume of each tumor and perform the histopathological analysis. The results showed that the DMBA control group presented mammary tumor development with histological characteristics of ductal carcinoma in situ and the presence of necrotic areas. Still, the groups that received the I. batatas extract demonstrated a decrease in tumor volume and, at the histological level, showed recovery of the duct. ductal and no areas of necrosis were evident. It is concluded that the ethanolic extract of the roots of Ipomoea batatas produces a decrease in tumor development in Rattus norvegicus var. albinus with induced breast cancer, this effect being dose-dependent.
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