Bibliographic citations
Vallenas, J., (2023). Eficacia protectiva e inmunogenicidad de una vacuna inactivada a base de cultivo celular contra la hepatitis A cuerpo de inclusión en pollos SPF [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/15152
Vallenas, J., Eficacia protectiva e inmunogenicidad de una vacuna inactivada a base de cultivo celular contra la hepatitis A cuerpo de inclusión en pollos SPF []. PE: Universidad Peruana Cayetano Heredia; 2023. https://hdl.handle.net/20.500.12866/15152
@mastersthesis{sunedu/3607247,
title = "Eficacia protectiva e inmunogenicidad de una vacuna inactivada a base de cultivo celular contra la hepatitis A cuerpo de inclusión en pollos SPF",
author = "Vallenas Romero, Juan Guillermo",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2023"
}
Inclusion Body Hepatitis (IBH) is a disease that affects poultry industries and causes severe economic losses due to the mortality, as well as a decrease in productive yields. The objective of this study was to evaluate the effectiveness of a vaccine developed in cell culture against HCI in Specific Pathogen Free (SPF) birds. For this, a trial was designed with 3 groups: Group 1 birds vaccinated and challenged with serotype 4 (FadV-4); Group 2 unvaccinated birds challenged with the same serotype; and Group 3 unvaccinated and non-challenged birds. The immunological response was evaluated by obtaining Geometric Average Titers (GAT) of antibodies in serum by ELISA, mortality, clinical signs, necropsy findings, and compatible IBH microscopic lesions. The results showed a higher GAT for group 1 (p<0.05) compared to group 2 and 3 at 17 days post-vaccination (986 vs 184 vs 85, respectively) and at 23 days post-vaccination (1551 vs 67 vs 96, respectively). At day 56, one week post challenge, the GAT was higher (p<0.05) for group 1 (7541, 1289 and 96, respectively) as well as at 14 days post challenge (15083, 4300 and 109, respectively). Mortality was only recorded for Group 2 (87.5%) as well as the presence of signs and lesions compatible with IBH. The experimental vaccine was able to counteract the onset and course of IBH disease in vaccinated birds.
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