Bibliographic citations
Macarlupu, J., (2023). Efecto de un plan controlado de ejercicio físico aeróbico submáximo sobre la oxigenación, marcadores eritropoyéticos y parámetros cardio-metabólicos en la eritrocitosis excesiva del Mal de Montaña Crónico [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/15244
Macarlupu, J., Efecto de un plan controlado de ejercicio físico aeróbico submáximo sobre la oxigenación, marcadores eritropoyéticos y parámetros cardio-metabólicos en la eritrocitosis excesiva del Mal de Montaña Crónico []. PE: Universidad Peruana Cayetano Heredia; 2023. https://hdl.handle.net/20.500.12866/15244
@phdthesis{renati/911217,
title = "Efecto de un plan controlado de ejercicio físico aeróbico submáximo sobre la oxigenación, marcadores eritropoyéticos y parámetros cardio-metabólicos en la eritrocitosis excesiva del Mal de Montaña Crónico",
author = "Macarlupu Bernuy, Jose Luis",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2023"
}
Excessive erythrocytosis (EE; [Hb]≥21g/dl) is the characteristic sign of Chronic Mountain Sickness (MMC), and treatments for this condition include bleeding, hemodilution, or transfer of the patient to a lower altitude. Studies have shown that native high-altitude athletes maintain hematocrit (Hct) within the range of sea level values and, therefore, we suggest that physical training may reduce excessive Hct and with it, the symptoms of MMC. The aim was to investigate the effect of training on high-altitude erythrocytosis in a rat animal model during hypoxia acclimation and in a human model of chronic hypoxia with MMC. For this, rats were studied during acclimatization to hypoxia (BP=433mmHg/1month) and a group of males from Cerro de Pasco (4340m) with MMC, both under a training plan of 1h/day-5days/week/4weeks. for animals, and 1h/day-4days/week/8weeks for humans. The results showed a significant reduction of Hct in both models, additionally the symptoms of MMC decreased significantly in humans. In conclusion, chronic hypoxia training decreases Hct and improves MMC symptomatology, suggesting that training could be used as a new management for MMC.
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