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Title: Riesgo cardiovascular y edad vascular como predictores de mortalidad en pacientes admitidos con diagnóstico de infección por COVID-19 en un centro hospitalario privado
Other Titles: Cardiovascular risk and vascular age as predictors of mortality in hospitalized adult patients with COVID-19 in a private hospital center
Advisor(s): Medina Palomino, Félix Alvaro; Loza Munarriz, César Antonio
OCDE field: http://purl.org/pe-repo/ocde/ford#3.02.04; http://purl.org/pe-repo/ocde/ford#3.02.08; http://purl.org/pe-repo/ocde/ford#3.03.08
Issue Date: 2023
Institution: Universidad Peruana Cayetano Heredia
Abstract: Antecedentes: Durante la pandemia por COVID-19, se observó que los factores de riesgo cardiovascular se asociaron con desenlaces adversos. Consecuentemente, se evaluó la asociación entre los puntajes de riesgo cardiovascular y la mortalidad. Objetivo: Determinar si el riesgo cardiovascular y la edad vascular son predictores de mortalidad intrahospitalaria en los pacientes admitidos por COVID-19 en un centro hospitalario privado. Materiales y métodos: Estudio de tipo descriptivo, retrospectivo, serie de casos, exploratorio. Se utilizó la regresión logística para evaluar la asociación entre el riesgo cardiovascular y la edad vascular con la mortalidad intrahospitalaria. Resultados: De 113 pacientes, 82.30% eran hombres. Las principales comorbilidades fueron obesidad (46.90%), hipertensión arterial (18.58%) y diabetes (10.62%). Finalmente, 18 pacientes fallecieron. Los pacientes con riesgo cardiovascular alto según Globorisk-LAC tuvieron significativamente mayor mortalidad intrahospitalaria, con un odds ratio ajustado (ORa) de 9.74 [(IC 95%: 1.07-88.53); p = 0.043]; igualmente, aquellos con riesgo cardiovascular moderado según el puntaje de Framingham, con ORa 5.43 [(IC 95%: 1.43-20.54); p=0.013]. Para aquellos con una edad vascular ≥ 65 años, el riesgo de mortalidad también fue mayor, con ORa 4.50 [(IC 95%: 1.35-14.98); p = 0.014]. Conclusión: El riesgo cardiovascular estimado por los puntajes de Globorisk-LAC y Framingham, y la edad vascular fueron predictores independientes de mortalidad intrahospitalaria en pacientes admitidos por COVID-19.

Background: During the COVID-19 pandemic, it was observed that cardiovascular risk factors were associated with adverse outcomes. Therefore, the association between cardiovascular risk scores and mortality was evaluated. Objectives: To determine if cardiovascular risk calculated and vascular age are predictors of in-hospital mortality in patients admitted for COVID-19 in a private hospital center. Material and methods: This was a descriptive, retrospective, case series, exploratory study. Logistic regression was used to evaluate the association between cardiovascular risk and vascular age with in-hospital mortality. Results Of 113 patients, 82.30% were men. The main comorbidities were obesity (46.90%), hypertension (18.58%) and diabetes (10.62%). Finally, 18 patients died. Patients with high cardiovascular risk according to Globorisk-LAC had significantly higher in-hospital mortality, with an adjusted odds ratio (ORa) of de 9.74 [(IC 95%: 1.07-88.53); p = 0.043]. Similarly, patients with moderate cardiovascular risk according to the Framingham score, had an ORa of 5.43 [(IC 95%: 1.43-20.54); p=0.013], respectively. For patients with vascular age ≥ 65 years, the risk of in-hospital mortality was also significantly higher, with an ORa of 4.50 [(IC 95%: 1.35-14.98); p = 0.014]. Conclusions Cardiovascular risk estimated by the Globorisk-LAC and Framingham score, and vascular age were independent predictors of in-hospital mortality in patients admitted for COVID-19.
Discipline: Medicina
Grade or title grantor: Universidad Peruana Cayetano Heredia. Facultad de Medicina Alberto Hurtado
Grade or title: Médico Cirujano
Juror: Huayanay Falconí, Leandro; Sosa Valle, Héctor Jesús; Anchante Hernández, Henry Alexander
Register date: 17-Jul-2023



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