Bibliographic citations
Garcia, S., (2021). Características de las infecciones recurrentes submicroscópicas por Plasmodium vivax detectadas durante un estudio cohorte de 3 años en la Amazonía peruana [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/10008
Garcia, S., Características de las infecciones recurrentes submicroscópicas por Plasmodium vivax detectadas durante un estudio cohorte de 3 años en la Amazonía peruana []. PE: Universidad Peruana Cayetano Heredia; 2021. https://hdl.handle.net/20.500.12866/10008
@misc{renati/910062,
title = "Características de las infecciones recurrentes submicroscópicas por Plasmodium vivax detectadas durante un estudio cohorte de 3 años en la Amazonía peruana",
author = "Garcia Castillo, Stefano Segundo Arturo",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2021"
}
Introduction: In the Peruvian Amazon, Plasmodium vivax malaria transmission is maintained because 1) recurrences in this region are extremely common; contributing to the increase of submicroscopic cases and 2) these infections are not detected by the Ministry of Health, thus perpetuating the silent transmission cycle. In this context, understanding the duration and evolution of these recurrent submicroscopic infections would allow us to understand their impact on the persistence of malaria. Methods: We conducted a retrospective analysis of monthly clinical and epidemiological data from two communities in Loreto (Cahuide and Lupuna) from 2013 to 2015. Survival analysis was performed to determine the probability of remaining free of recurrences. Likewise, the association of factors with detection time was sought through Cox regression analysis. Finally, the incidence density (ID) of the evolution from submicroscopic infection to microscopic infection and undetectable infection was determined. Results: During the three years of follow-up, about 57% (195/343) of the individuals had at least one recurrence, of which 30.79% (93/195) had a recurrence in the first three months after microscopic infection. The probability of remaining free of recurrences 6 months after infection was 66% by microscopy and 62.6% by PCR. In turn, the time to detection was found to be associated with factors such as community, age, occupation, number of malaria episodes in their lifetime and type of nets used. The ID of submicroscopic infections becoming microscopic was 1.43 and of becoming undetectable was 22.81 per 100 person-years. Conclusion: We determined the time to detection and evolution of submicroscopic infections, and how the use of microscopy alone does not show the full picture of recurrences. This information is relevant so that the current "Zero Malaria Plan" program of the Ministry of Health can design better strategies focusing its resources on the active search for submicroscopic malaria infections.
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