Citas bibligráficas
Lara, L., López, E. (2024). Síntesis y caracterización de nanopartícula de sílice con ácido clorogénico y evaluación de su capacidad antioxidante [Universidad Nacional de Trujillo]. https://hdl.handle.net/20.500.14414/22479
Lara, L., López, E. Síntesis y caracterización de nanopartícula de sílice con ácido clorogénico y evaluación de su capacidad antioxidante []. PE: Universidad Nacional de Trujillo; 2024. https://hdl.handle.net/20.500.14414/22479
@misc{renati/880432,
title = "Síntesis y caracterización de nanopartícula de sílice con ácido clorogénico y evaluación de su capacidad antioxidante",
author = "López León, Esthefani Elizabeth",
publisher = "Universidad Nacional de Trujillo",
year = "2024"
}
ABSTRACT Due to the low bioavailability and, therefore, low efficacy of drugs, it has been decided to develop new forms of molecules together with nanotechnology, in order to obtain particles capable of serving as transport media for other molecules. Thus, this study aims to synthesize and characterize silica nanoparticles with chlorogenic acid and evaluate their antioxidant capacity, where the synthesis of silica nanoparticles is described by the modified Stöber method, using Tetraethyl orthosilicate (TEOS) as a precursor of silica nanoparticles. In nature, there are several chemical compounds with outstanding antioxidant characteristics, and one of these is chlorogenic acid. To assess this characteristic, an evaluation was carried out through chemical reactions, one of them being with 2,2-diphenyl-1-picrylhydrazyl (DPPH). Then, an immediate measurement was made in the UV at 517nm with absolute ethanol, in order to evaluate the antioxidant capacity. To characterize and determine the morphology of these compounds, techniques such as Fourier infrared spectroscopy (FTIR) were used, where we identified the hydroxyl, silanol and carbonyl groups; which have a good colloidal stability due to their Z potential; the scanning electron microscopy (SEM) method and dynamic light scattering (DLS) were also used, where a distribution of spherical nanoparticles of size 579 nm, uniform in size and dispersed on the surface, is shown. Finally, from the analysis of results it is concluded that the synthesis of silica nanoparticles with chlorogenic acid was successful and when evaluating its antioxidant capacity, an inhibition percentage of 15% was obtained.
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