Bibliographic citations
Toribio, P., Vera, R., Nizama, L. (2021). Alteraciones electrocardiográficas en pacientes mayores de 40 años con leishmaniasis tegumentaria en tratamiento con antimoniales pentavalentes [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/9329
Toribio, P., Vera, R., Nizama, L. Alteraciones electrocardiográficas en pacientes mayores de 40 años con leishmaniasis tegumentaria en tratamiento con antimoniales pentavalentes []. PE: Universidad Peruana Cayetano Heredia; 2021. https://hdl.handle.net/20.500.12866/9329
@misc{renati/493725,
title = "Alteraciones electrocardiográficas en pacientes mayores de 40 años con leishmaniasis tegumentaria en tratamiento con antimoniales pentavalentes",
author = "Nizama Zevallos, Luis Alberto",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2021"
}
Background: Pentavalent antimonials still are the first-line treatment for tegumentary leishmaniasis, despite being cardiotoxic. There are few studies on electrocardiographic alterations in patients over 40 years old, being a risk group for the development of cardiotoxicity. Objective: To describe electrocardiographic alterations in patients over 40 years old with tegumentary leishmaniasis treated with pentavalent antimonials. Material and methods: Case series. 1.057 patients with tegumentary leishmaniasis were treated from 2015 to 2019 in the Leishmaniasis Programme, selecting 150 patients over 40 years old with an electrocardiogram at the beginning and the end of treatment. Results: The ratio male/female was 2.2, 37/150 patients were over 65 years old, 24/150 had mucocutaneous disease, 30/150 had comorbidities associated with QT interval prolongation (arterial hypertension, type 2 diabetes mellitus, obesity, hypothyroidism or smoking history), 117/150 used dose of 20mgSb5+/kg/day. There was an increase in the frequency of prolonged QTc intervals (7/150 vs 13/150). QTc interval increased by 12.06ms (95% CI 6.35 to 17.77ms). The frequency of T wave alterations increased (51/150 vs 74/150). T wave amplitude decreased by 0.35mV (95% CI 0.25 to 0.45mV). There were no alterations in terms of the PR interval or QRS complex. Ventricular arrhythmias or deaths were not reported. Conclusions: Pentavalent antimonials cause cardiotoxicity, evidenced by an increase of QT interval and decrease in the T wave amplitude in patients over 40 years old.
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