Bibliographic citations
Espinoza, N., (2005). Estudio comparativo de la influencia del material de empaque primario sobre las tabletas recubiertas de lamivudina 150 mg. [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/2605
Espinoza, N., Estudio comparativo de la influencia del material de empaque primario sobre las tabletas recubiertas de lamivudina 150 mg. [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2005. https://hdl.handle.net/20.500.12672/2605
@misc{renati/493006,
title = "Estudio comparativo de la influencia del material de empaque primario sobre las tabletas recubiertas de lamivudina 150 mg.",
author = "Espinoza Cámac, Nataly Valentina",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2005"
}
The aim of this the present study was to evaluate the influence of four different primary package materials that are used regularly for tablets, over a formulation by direct compression of lamivudine 150 mg coated tablet. The pilot-size batch was packed in the next primary package material used in this study: PVC (polyvinyl chloride) / Aluminum, PVC/PVdC (polyvinylidene chloride) / Aluminum, PVC/PCTFE (Polychlorotrifluoroethylene) / Aluminum and polyethylene aluminum foil “Alupol/Alupol”. At last these product were include in an accelerated stability study during six months to conditions of recommended temperature and humidity for Peru (zone IV) according to the United States Pharmacopeia 27 (USP27). In order to determine the material of suitable packing parameters test were developed during the stability study. At the end of the study, all the evaluated materials of packing guarantee the quality of the product. Then the economic analysis of each material of used packing was achieved, to establish which material allows to save costs without affecting the quality of the product. Finally considering the aspects of quality, logistic, cost and marketing, it is concluded that the PVC is the material of suitable packaging but for the product of integral way.
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