Bibliographic citations
Tinco, J., (2010). Efecto modulador de la erección por el extracto metanólico de Jatropha macrantha Müll. Arg. “huanarpo macho“ en ratas con inducción de disfunción eréctil [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/792
Tinco, J., Efecto modulador de la erección por el extracto metanólico de Jatropha macrantha Müll. Arg. “huanarpo macho“ en ratas con inducción de disfunción eréctil [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2010. https://hdl.handle.net/20.500.12672/792
@phdthesis{renati/490294,
title = "Efecto modulador de la erección por el extracto metanólico de Jatropha macrantha Müll. Arg. “huanarpo macho“ en ratas con inducción de disfunción eréctil",
author = "Tinco Jayo, Johnny Aldo",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2010"
}
The objective was to determine the effect modulator of the erection for the extract metanólico of jatropha macrantha Müll Arg. “huanarpo macho“ in rats with induction of erectile disfunción. Collect you leaves and shafts of the district of Vilcashuamán, department of Ayacucho to obtain the extract metanólico, the march fitoquímica I identify fenoles, tannins, lactonas, cumarinas, triterpernos, flavonoides, alkaloids, and catequinas; confirming is witnessed of flavonoides by means of technical cromatográficas UV, to go, being carried out the separation of having composed by cromatografía in fine layer, obtaining you fractions purified by means of cromatografía to scale preparativa using diverse systems of solvents, being elucidated structurally by means of technical spectrofotométricas the different flavonoides types. Lethal dose (DL50) was of 1357mg/Kg in mice; being evaluated the sexual behavior to 100, 200 and 300 mg/kg, control and sildenafilo citrato 5 mg/kg. being Achieved a better effect of frequency of it mounts dependent dose comparatively to the group control and the sidenafilo (p less than 0,05); what allowed to determine a dose effective stocking (DEM) of 157.1 mg/Kg, percentage of variation of 71.11; 95% and 75; 100 effect% for 200,300 mg/Kg, constituting the most important parameter. The plasmatic level of I oxidize nitric in plasm he had values of 4.75 and 5.32, and sidenafilo 6.25 umol/ml, variation percentage and effect (32.4,39.2; 82.66, 100) to 200 and 300 mg/Kg being an effect dependent dose (p less thab 0,05), the same as in isolated organs to 50,100 and 300 ug/ml and those of L-arginina 300 uM, acetilcolina 30uM, epinephrine u/ml and sildenafilo (Viagra)(3.2×10-5 mg/ml). Experimentally a marked effect modulator of the erection of the penis has been demonstrated by influence of the extract metanólico in rats with induction of erectile disfunción.
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