Bibliographic citations
Varas, R., (2009). Efecto citoprotector y antisecretor gástrico del extracto acuoso de Solanum americanum Mill (Hierba mora) en inducción de úlcera gástrica en ratas [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/225
Varas, R., Efecto citoprotector y antisecretor gástrico del extracto acuoso de Solanum americanum Mill (Hierba mora) en inducción de úlcera gástrica en ratas [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2009. https://hdl.handle.net/20.500.12672/225
@misc{renati/489346,
title = "Efecto citoprotector y antisecretor gástrico del extracto acuoso de Solanum americanum Mill (Hierba mora) en inducción de úlcera gástrica en ratas",
author = "Varas Ponce, Rocío Jovanna",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2009"
}
Aim: The aim of this study was to determine the cytoprotective and antisecretory effect of extract aqueous of Solanum americanum Mill (hierba mora) in rats with gastric ulcer induced and to observe the presence of adverse reactions. Methods: We used 72 rats were divided en groups of 6. For the cytoprotective effect, the ulcer was induced by administration of indomethacin 30mg/kg b.w.; the antisecretory effect by pylorus ligation and to evaluate the adverse reactions the extract was administered for two months, the doses of extract were 200mg / kg and 400mg/kg, which were compared with omeprazole at a dose of 10mg/kg. Results: Treatment with extract of S. americanum Mill at a dose of 400mg/kg b.w., showed cytoprotective effect, decreasing in 67% the indicators of congestion, edema and hemorrhage induced with indomethacin, however omeprazole decreased 67% the indicators of congestion and hemorrhage, and 100% the indicator of edema. In pylorus-ligated, the extract aqueous of S. americanum Mill a dose of 400mg/kg b.w., showed antisecretory effect, decreasing the volume of gastric secretion in 66% and increasing pH in 163%, and the omeprazole reduced the gastric acid secretion in 83.6% and increased the pH in 201.5%. In the determination of adverse effects, S. americanum Mill proved to be safe at doses of 400mg/kg b.w. Conclusion: In the experimentals conditions, the extract aqueous of S. americanum Mill possesses antisecretory and cytoprotective effect in rats with induced gastric ulcer, and with minimal side effects.
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