Bibliographic citations
Milla, D., (2013). Evaluación de fibrinógeno plasmático en pacientes con enfermedad periodontal en el Centro Médico Naval Cirujano Mayor Santiago Távara en el año 2013 [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/3476
Milla, D., Evaluación de fibrinógeno plasmático en pacientes con enfermedad periodontal en el Centro Médico Naval Cirujano Mayor Santiago Távara en el año 2013 [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2013. https://hdl.handle.net/20.500.12672/3476
@misc{renati/486801,
title = "Evaluación de fibrinógeno plasmático en pacientes con enfermedad periodontal en el Centro Médico Naval Cirujano Mayor Santiago Távara en el año 2013",
author = "Milla Torres, Daniela Fernanda",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2013"
}
--- Periodontal disease is a chronic infection caused primarily by Gram-negative anaerobic bacteria that grow inflammatory activity within the gingival sulcus forming subgingival plaque. Bacteria and their products stimulate host cells to release inflammatory mediators such as cytokines and prostaglandins that coordinate the mad and systemic inflammatory response that exacerbate the damage or destruction of periodontal tissues. The pro -inflammatory cytokines that originate at the site of local pathology will stimulate hepatocytes to produce acute phase proteins including fibrinogen who is part of the non-specific response. The relationship between bacteria and the mechanisms of the host immune response is the basis of immunopathological mechanism of tissue damage. Many studies have shown that fibrinogen is an important independent risk factor for coronary heart disease and is often used as a marker of inflammation. The increased plasma fibrinogen concentration is related to the development of coronary heart disease by changing the mechanism of platelet aggregation by increasing the amount of fibrin formed and accumulated, which is related to the evolution of the atherosclerotic plaque, and an increase blood viscosity related to the risk of thrombosis. The objective of this research was to test whether the presence of periodontal disease increases systemic fibrinogen level , which could add evidence for causal relationship between periodontal disease and cardiovascular disease . For this, 40 patients who met certain criteria to form 03 groups, one gingivitis control group ( n = 10), a group of patients with localized periodontal disease (n = 15 ) and a group of patients with generalized periodontal disease were selected (n = 15 ) . After evaluating the results obtained to those with localized or generalized periodontal disease have levels higher than periodontally healthy patients plasma fibrinogen, these differences are statistically significant (P < 0.05). Significant differences between the group mean gingivitis ( X = 276.80 ) and the group average periodontal disease localized ( X = 330.53 ) ( P = 0.012 ) was found and was also found that there is significant difference between the mean gingivitis group and periodontal disease generalized ( X = 336.07 ) ( P = 0.005 ) , but no significant differences between groups of localized and generalized periodontal disease . We conclude that the presence of periodontal disease causes elevation of plasma fibrinogen level, then we could reaffirm the premise that periodontal disease is an independent risk indicator for cardiovascular events. But still more research in this area is needed to confirm the interconnection between the two diseases.
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