Bibliographic citations
Villacorta, A., Dotto, G. (2023). Lymphocyte-to-monocyte ratio and clinical outcomes in Cholangiocarcinoma: A systematic review and meta-analysis [Tesis, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/667441
Villacorta, A., Dotto, G. Lymphocyte-to-monocyte ratio and clinical outcomes in Cholangiocarcinoma: A systematic review and meta-analysis [Tesis]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2023. http://hdl.handle.net/10757/667441
@misc{renati/404442,
title = "Lymphocyte-to-monocyte ratio and clinical outcomes in Cholangiocarcinoma: A systematic review and meta-analysis",
author = "Dotto Vasquez, Giuseppe",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2023"
}
Background and aims: Lymphocyte-to-Monocyte Ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and survival outcomes for cholangiocarcinoma patients. Materials and Methods: A systematic review and meta-analysis was performed to assess the association between LMR and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used hazard ratios (HRs) and their 95% confidence intervals (CIs) as a measure of effect for the random effect model meta-analysis. The Newcastle-Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. Results: A total of 19 studies were included in this study (n=3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71-0.96; I2=86%) and TTR (HR: 0.71; 95% CI: 0.58-0.86; I2=0%). DFS and RFS also were evaluated; however, they did not show statistically significant associations. Conclusion: Low LMR values were associated with worse OS and TTR.
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