Bibliographic citations
Correa, W., (2023). Variabilidad hemodinámica entre bupivacaína isobárica vs bupivacaína hiperbárica en cesáreas. Un estudio de cohortes prospectivo [Tesis, Universidad Privada Antenor Orrego - UPAO]. https://hdl.handle.net/20.500.12759/10802
Correa, W., Variabilidad hemodinámica entre bupivacaína isobárica vs bupivacaína hiperbárica en cesáreas. Un estudio de cohortes prospectivo [Tesis]. PE: Universidad Privada Antenor Orrego - UPAO; 2023. https://hdl.handle.net/20.500.12759/10802
@misc{renati/372513,
title = "Variabilidad hemodinámica entre bupivacaína isobárica vs bupivacaína hiperbárica en cesáreas. Un estudio de cohortes prospectivo",
author = "Correa Cerro, Wendy Katiuska",
publisher = "Universidad Privada Antenor Orrego - UPAO",
year = "2023"
}
Objective: To compare the effects of isobaric and hyperbaric bupivacaine on hemodynamic alterations after administering spinal anesthesia during the development of the caesarean section. Methodology: Prospective cohort, 194 pregnant women going through surgical procedure by caesarean section at “Hospital de Apoyo Sullana II-2” hospital., which were divided into two groups: the exposed group, which used hyperbaric bupivacaine; and the non-exposed group, which received isobaric bupivacaine treatment. A univariate analysis was performed using tables of frequencies and percentages. For the numerical variables the mean and standard deviation were used. Additionally, multivariate analysis was performed. Results: The unexposed group had twice the risk (RR: 2.076; 95% CI: 1.576-2.790) of needing to use treatment for the reversal of hemodynamic changes. Treatment for reversal of hemodynamic changes was required in 75.7% of patients who received isobaric bupivacaine compared with 39.2% of the patients who received hyperbaric bupivacaine (p<0.01). The multivariate analysis concluded that hyperbaric bupivacaine decreases the risk of hemodynamic variability by 82% (Exp B: 0.18, p: 0.001; IC: 0.09 – 0.36) when adjusted to clinical variables such as: age, BMI, week of gestation, number of previous cesarean sections; and surgical variables, such as anesthesiologic risk. Conclusions: Isobaric bupivacaine caused greater hemodynamic changes (hypotension and bradycardia) than hyperbaric bupivacaine, doubling the risk of developing hemodynamic variations, while the consequent use of treatment for the reversal of the previously mentioned variations is related to a longer stay in the postanesthetic recovery unit.
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