Bibliographic citations
Canelo, P., Mendoza, Y. (2017). Efecto hepatoprotector del extracto acuoso liofilizado de Curcuma longa L. en daño hepático agudo inducido por tetracloruro de carbono en ratas albinas [Tesis, Universidad Nacional de la Amazonía Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/4879
Canelo, P., Mendoza, Y. Efecto hepatoprotector del extracto acuoso liofilizado de Curcuma longa L. en daño hepático agudo inducido por tetracloruro de carbono en ratas albinas [Tesis]. : Universidad Nacional de la Amazonía Peruana; 2017. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/4879
@misc{renati/286421,
title = "Efecto hepatoprotector del extracto acuoso liofilizado de Curcuma longa L. en daño hepático agudo inducido por tetracloruro de carbono en ratas albinas",
author = "Mendoza Gardini, Yrani Kateri",
publisher = "Universidad Nacional de la Amazonía Peruana",
year = "2017"
}
Hepatic damage is an inflammation of the parenchyma, caused by different factors such as xenobiotic agents and a diet unbalanced in nutrients, causing apoptosis of the liver tissue. The hepatoprotective effect of the lyophilized aqueous extract of Curcuma longa L. against the acute liver damage produced by carbon tetrachloride in albino rats was evaluated. They were divided into 5 groups with 4 members: negative control and positive control (CCl4) were administered with distilled water (0.5 ml/kg, po); (100 mg/kg, po) and silymarin group (100 mg/kg, po), respectively. The duration of the treatment lasted 7 days; on day 6 and 7, after 12 hours of fasting, except for the negative control group, were treated with 2 ml CCl4. The blood sample was collected 24 hours after CCl4 administration; under anesthesia with ketamine/xylazine/atropine, for the estimation of biochemical markers of ALT, AST and ALP, and then the animals were sacrificed for the histopathological study. The positive group showed an increase of ALT, AST and ALP with respect to the negative control group (p<0.05). Experimental groups of turmeric (100 mg and 200 mg) with CCl4 showed a significant decrease (p<0.05). In the serum levels of AST, ALT and ALP. In histological observation the turmeric group 200 mg/kg showed a normal structure of the liver tissue, with respect to the positive control group. Thus, the results show that turmeric, planted in our Amazon Region, has a hepatoprotective effect against CCl4.
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