Bibliographic citations
Saldaña, L., (2019). Toxicidad aguda del extracto acuoso de hojas de Calathea lutea bijao en ratones albinos BALB/C [Tesis, Universidad Nacional de la Amazonía Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6139
Saldaña, L., Toxicidad aguda del extracto acuoso de hojas de Calathea lutea bijao en ratones albinos BALB/C [Tesis]. : Universidad Nacional de la Amazonía Peruana; 2019. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6139
@misc{renati/285210,
title = "Toxicidad aguda del extracto acuoso de hojas de Calathea lutea bijao en ratones albinos BALB/C",
author = "Saldaña Mora, Layne Valeria",
publisher = "Universidad Nacional de la Amazonía Peruana",
year = "2019"
}
The objective of the present investigation was to determine the acute toxicity of the aqueous extract of Calathea lutea "bijao" leaves in albino mice Mus musculus Balb/C ". It was an experimental study, of the prospective, transversal type. It had as animal sample of 12 male Balb/C albino mice, distributed a negative control group and 3 experimental groups previous fasting the aqueous extract was administered orally at a single dose of leaves of Calathea lutea “bijao” was administered 25 mg/kg, 200 mg/kg and 2000 mg/kg dose. The body weight of the mice was recorded on day one, seven and fourteen. The most important results were: We obtained a 7,23% yield per 100 g. of dry leaf. During the experimentation time, an increase of approximately 17, 52% of the average weight was observed from the first to the seventh day, and a decrease of approximately 15, 45% of the average weight from the seventh to the fourteenth day. Regarding the macroscopic observation of acute toxicity of the organs and systems, mild sedation was observed at the behavioral level in all groups, and mild erection was observed at the cutaneous and autonomous systems at a dose of 200 mg/kg body weigth. Likewise, hepatic enlargement was evident in group 2 (200 mg/kg) and predominance in 3 (2000 mg/kg doses) with a variation of 1,97 g in weight between the groups, meaning an increase of approximately 80% of the basal and 30% of the total body weight of the mouse. Therefore, it can be concluded that the aqueous extract of Calathea lutea “bijao” leaves present a possible toxic or noxious effect in the experimental animals when significant clinical alterations were observed at the hepatic level compared to the negative control group.
This item is licensed under a Creative Commons License