Bibliographic citations
Bengoa, A., Valle, R. (2025). Ingesta dietética de flavonoides y la incidencia de demencia en adultos mayores de 45 años: una revisión sistemática [Tesis, Universidad Peruana de Ciencias Aplicadas (UPC)]. http://hdl.handle.net/10757/684256
Bengoa, A., Valle, R. Ingesta dietética de flavonoides y la incidencia de demencia en adultos mayores de 45 años: una revisión sistemática [Tesis]. PE: Universidad Peruana de Ciencias Aplicadas (UPC); 2025. http://hdl.handle.net/10757/684256
@misc{renati/1959911,
title = "Ingesta dietética de flavonoides y la incidencia de demencia en adultos mayores de 45 años: una revisión sistemática",
author = "Valle García, Reiji Francesco",
publisher = "Universidad Peruana de Ciencias Aplicadas (UPC)",
year = "2025"
}
Objective: To systematize the literature evaluating the association between dietary flavonoid intake and the incidence of dementia in adults aged 45 years and older. Methods: A systematic review of 14 cohort studies published up to April 2022 was conducted in Embase, PubMed, Scopus, and Scielo. Studies assessing dietary flavonoid intake with validated tools and outcomes such as cognitive impairment, Alzheimer’s disease, and Parkinson’s disease were included. Study quality was assessed using the Newcastle-Ottawa scale, with scores ranging from 6 to 9. Results: Out of a total of 1,525 articles, 14 cohort studies were included, encompassing 170,846 participants aged between 45 and 98 years. The results established significant associations between high flavonoid consumption, particularly flavonols and anthocyanins, and a lower risk of cognitive decline and Alzheimer’s disease in two studies with high methodological quality. However, heterogeneity in evaluation methods and biases associated with dietary questionnaires hindered comparability. Additionally, the lack of biomarker analysis and inconsistent application of cognitive tools may limit the validity of the findings. Conclusion: Flavonoids may have a protective effect against dementia, although current methodological limitations make it difficult to draw definitive conclusions. Future research is suggested to employ more homogeneous designs, include biomarkers, and improve the control of confounding factors to strengthen the evidence base.
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