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Merino, S., (2021). Asociación entre pronóstico y los factores de riesgo del linfoma no Hodgkin de células B [Tesis, Universidad Privada Antenor Orrego]. https://hdl.handle.net/20.500.12759/7572
Merino, S., Asociación entre pronóstico y los factores de riesgo del linfoma no Hodgkin de células B [Tesis]. PE: Universidad Privada Antenor Orrego; 2021. https://hdl.handle.net/20.500.12759/7572
@misc{renati/1358857,
title = "Asociación entre pronóstico y los factores de riesgo del linfoma no Hodgkin de células B",
author = "Merino Ramos, Shirley Lizbeth",
publisher = "Universidad Privada Antenor Orrego",
year = "2021"
}
Title: Asociación entre pronóstico y los factores de riesgo del linfoma no Hodgkin de células B
Authors(s): Merino Ramos, Shirley Lizbeth
Advisor(s): Aliaga Cajan, Jorge Eduardo
Keywords: Linfoma no Hodgkin; VIH; Herbicidas; Plaguicidas; Pronóstico
OCDE field: https://purl.org/pe-repo/ocde/ford#3.02.27
Issue Date: 2021
Institution: Universidad Privada Antenor Orrego
Abstract: El linfoma no Hodgkin (LNH) es una neoplasia hematológica. Se han considerado
que ciertos factores; como la exposición a agentes infecciosos (Helicobacter pylori
y Virus de Epstein Barr), el VIH-SIDA y las exposiciones a químicos (herbicidas);
podrían aumentar el desarrollo del cáncer, además el pronóstico nos puede
ayudar a plantear mejor el tratamiento.
Objetivo: Analizar la asociación entre el pronóstico y los factores de riesgo del
Linfoma no Hodgkin de células B, en pacientes entre los 40 y 80 años del Hospital
III Essalud José Cayetano Heredia, Piura, Enero de 2013 a Julio de 2019.
Material y método: Estudio observacional, analítico, transversal y retrospectivo,
donde se estudió a 112 pacientes. El análisis estadístico incluyó la prueba Chi
cuadrado y un valor de p < 0.05 se consideró estadísticamente significativo, se
determinó la fuerza de asociación mediante la regresión logística binaria.
Resultado: El año 2018 se registró mayor cantidad de casos (22,3%). Tuvieron
buen pronóstico (BP) 42,9% y mal pronóstico (MP) 57,1%. El grupo etario 60-80
años (55,4%), sexo masculino (53,6%) y procedencia Piura (51,8%). El subtipo
histológico de Linfoma difuso de células B grandes (81,3%). Tuvieron exposición a
agentes infecciosos el 61,6% con un Odds Ratio 2,778 y un Exp(B) de 2,2.
Conclusiones: El LHN de células B es más frecuente en pacientes adultos
mayores, sin diferencia significativa en el sexo. En los factores de exposición, los
pacientes que tuvieron exposición a los agentes infecciosos tienen 2,2 veces
mayor riesgo de desarrollar mal pronóstico.
Non-Hodgkin's lymphoma (NHL) is a haematological neoplasm. Certain factors have been considered; exposure to infectious agents (Helicobacter pylori and Epstein Barr Virus), HIV-AIDS and exposures to chemicals (herbicides); that could increase the development of this cancer, and the prognosis could help us better develop treatment. Objective: To analyze the association between the prognosis and risk factors of B-cell non-Hodgkin lymphoma in patients between 40 and 80 years of age at Hospital III Essalud José Cayetano Heredia, Piura, January 2013 to July 2019. Material and method: Observational, analytical, transversal and retrospective study. The statistical analysis included the Chi squared test and a value of p <0.05 was considered statistically significant, the association force will be determined by binary logistic regression. Results: The year 2018 recorded the highest number of cases (22,3%). They had good prognosis (BP) 42,97% and poor prognosis (MP) 57,1%. The age group 60-80 years (55,4%), male sex (53,6%), Piura (51,8%). The histological subtype of large B-cell diffuse lymphoma (81,3%). They had exposure to infectious agents 61,6% and a Odds Ratio 2,778 and an Exp(B) of 2,2. Conclusions: B-cell LHN is common in older adult patients, more prevalent diagnosis of sub-type is large B-cell diffuse lymphoma, with no significant difference in sex. In exposure factors, patients had exposure to infectious agents have a 2,2 times higher risk of poor prognosis.
Non-Hodgkin's lymphoma (NHL) is a haematological neoplasm. Certain factors have been considered; exposure to infectious agents (Helicobacter pylori and Epstein Barr Virus), HIV-AIDS and exposures to chemicals (herbicides); that could increase the development of this cancer, and the prognosis could help us better develop treatment. Objective: To analyze the association between the prognosis and risk factors of B-cell non-Hodgkin lymphoma in patients between 40 and 80 years of age at Hospital III Essalud José Cayetano Heredia, Piura, January 2013 to July 2019. Material and method: Observational, analytical, transversal and retrospective study. The statistical analysis included the Chi squared test and a value of p <0.05 was considered statistically significant, the association force will be determined by binary logistic regression. Results: The year 2018 recorded the highest number of cases (22,3%). They had good prognosis (BP) 42,97% and poor prognosis (MP) 57,1%. The age group 60-80 years (55,4%), male sex (53,6%), Piura (51,8%). The histological subtype of large B-cell diffuse lymphoma (81,3%). They had exposure to infectious agents 61,6% and a Odds Ratio 2,778 and an Exp(B) of 2,2. Conclusions: B-cell LHN is common in older adult patients, more prevalent diagnosis of sub-type is large B-cell diffuse lymphoma, with no significant difference in sex. In exposure factors, patients had exposure to infectious agents have a 2,2 times higher risk of poor prognosis.
Link to repository: https://hdl.handle.net/20.500.12759/7572
Discipline: Medicina Humana
Grade or title grantor: Universidad Privada Antenor Orrego. Facultad de Medicina Humana
Grade or title: Médico Cirujano
Juror: Valencia Mariñas, Hugo David; Yan Quiroz, Edgar Fermin; Guzman Ventura, Wilmer Valdemar
Register date: 31-May-2021
This item is licensed under a Creative Commons License