Bibliographic citations
Medina, M., (2024). Efectividad de atropina 0.01% e intervenciones de corrección óptica para ralentizar miopía infantil: revisión sistemática [Tesis, Universidad Privada Antenor Orrego]. https://hdl.handle.net/20.500.12759/40971
Medina, M., Efectividad de atropina 0.01% e intervenciones de corrección óptica para ralentizar miopía infantil: revisión sistemática [Tesis]. PE: Universidad Privada Antenor Orrego; 2024. https://hdl.handle.net/20.500.12759/40971
@phdthesis{renati/1358794,
title = "Efectividad de atropina 0.01% e intervenciones de corrección óptica para ralentizar miopía infantil: revisión sistemática",
author = "Medina Huayta, Mareyke Natividad",
publisher = "Universidad Privada Antenor Orrego",
year = "2024"
}
To determine the effectiveness of 0.01% atropine combined with optical correction interventions in slowing the progression of childhood myopia. Methodology. A systematic search was conducted in the main databases, reviewing titles and abstracts, followed by full-text reviews. The risk of bias was assessed based on the study design, and a meta-analysis was performed using random effects by study design subgroups and optical correction. Heterogeneity was evaluated through the I2 coefficient. Main Results. Six studies were included: four randomized clinical trials, one non-randomized trial, and one cohort study. A total of 518 patients with low to moderate myopia were included, with 290 in the combined therapy group and 288 in the monotherapy group, with a minimum follow-up period of one year. All studies evaluated the combined therapy of 0.01% atropine with orthokeratology compared to monotherapy with orthokeratology. In the meta-analysis by study design and orthokeratology with and without 0.01% atropine at one year of follow-up, a mean axial length difference of -0.10 mm was found in favor of the combined therapy group with a 95% CI of -0.12 to -0.07, but with high risk of bias and moderate heterogeneity (I2 31%). No serious adverse events were reported, and no rebound effect was observed. Conclusions. According to the synthesized evidence, combined therapy with 0.01% atropine and orthokeratology compared to orthokeratology alone could slow low to moderate childhood myopia, the studies are heterogeneous and have a high risk of bias, results are statistically significant but without clinical relevance., which does not justify a change in usual clinical practice. Registration: PROSPERO (CRD42022301646)
This item is licensed under a Creative Commons License