Bibliographic citations
Renteria, A., (2021). Eficacia del Ondansetron vs Dimenhidrinato para manejar náuseas y vómitos tras colecistectomía laparoscópica en una clínica de Piura [Tesis, Universidad Privada Antenor Orrego]. https://hdl.handle.net/20.500.12759/8302
Renteria, A., Eficacia del Ondansetron vs Dimenhidrinato para manejar náuseas y vómitos tras colecistectomía laparoscópica en una clínica de Piura [Tesis]. PE: Universidad Privada Antenor Orrego; 2021. https://hdl.handle.net/20.500.12759/8302
@misc{renati/1343631,
title = "Eficacia del Ondansetron vs Dimenhidrinato para manejar náuseas y vómitos tras colecistectomía laparoscópica en una clínica de Piura",
author = "Renteria Mogrovejo, Adriana Fiorella",
publisher = "Universidad Privada Antenor Orrego",
year = "2021"
}
Objective: Evaluate the efficacy in the management of postoperative nausea and vomiting of ondansetron compared to dimenhydrinate in patients who underwent laparoscopic cholecystectomy in a private clinic in Piura, during 2019. Methods: The present study corresponded to a prospective, observational, cohort study was conducted in which the efficacy of two drugs (ondansetron vs dimenhydrinate) was compared. It included patients who underwent laparoscopic cholecystectomy in a private clinic in Piura, during 2019. A sample of 66 patients (33 received ondansetron and 33 dimenhydrinate) was calculated for this study. For the inferential analysis, the Stata program was applied to calculate confidence intervals for means, proportions and variances, with a confidence level of 95% Results: The prevalence of postoperative nausea and vomiting (PONV) in patients who received ondansetron was 21.2% (95%CI: 8.9-38.9), while with dimenhydrinate it was 21.2% (95%CI: 8.9-38.9), identifying that ondansetron presented a lower prevalence of PONV (p=0.044). It was found that during patient follow-up (4 hours), less PONV was reported with ondansetron than with dimenhydrinate (p<0.05). Regarding the amount of nausea during follow-up, this was lower with ondansetron than with dimenhydrinate (p=0.045) and similarly lower number of vomiting events (p<0.001). The time to onset of postoperative nausea (p=0.032) and vomiting (p=0.021) was longer among those receiving ondansetron. Rescue antiemetic use was employed in 12.1% (95%CI: 3.4-28.2) with dimenhydrinate and in 3% (1.9-24.3) with dimenhydrinate. Conclusions: The results of this study show the efficacy of the use of ondansetron for the management of PONV, compared to another widely used antiemetic such as dimenhydrinate.
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