Bibliographic citations
Chavez, S., Tineo, L. (2024). “Resistencia a antibióticos de E. coli enterotoxigénica asociada al consumo de antibióticos en una cohorte de niños de 0 a 2 años en Lima (2016-2019)” [Universidad Peruana Cayetano Heredia]. https://hdl.handle.net/20.500.12866/16453
Chavez, S., Tineo, L. “Resistencia a antibióticos de E. coli enterotoxigénica asociada al consumo de antibióticos en una cohorte de niños de 0 a 2 años en Lima (2016-2019)” []. PE: Universidad Peruana Cayetano Heredia; 2024. https://hdl.handle.net/20.500.12866/16453
@misc{renati/1281908,
title = "“Resistencia a antibióticos de E. coli enterotoxigénica asociada al consumo de antibióticos en una cohorte de niños de 0 a 2 años en Lima (2016-2019)”",
author = "Tineo Flores, Luz Marianela",
publisher = "Universidad Peruana Cayetano Heredia",
year = "2024"
}
Antibiotic resistance is considered one of the 10 main health problems worldwide, especially affecting the pediatric population due to limited therapeutic options for the management of recurrent infections. This problem is aggravated by the high consumption of antibiotics in childhood, which could contribute to an increase in bacterial resistance. Therefore, the aim of this study was to evaluate the association between cumulative antibiotic consumption and resistance in ETEC colonies, isolated from stool samples of children aged 0 to 2 years in Villa El Salvador, between 2016 and 2019. This is a secondary study of data and samples taken from a cohort study of children in Villa El Salvador, which obtained data on daily antibiotic consumption in their first 2 years of life and also obtained ETEC colonies from one or more infections that the children had in that same period. The variability in antibiotic consumption allowed us to divide this study population into the control group (children with a report of 0, 1 and 2 antibiotic intakes), and the exposed group (children with a report of 10 - 26 antibiotic intakes). After reactivation of the stored cultures, ETEC colonies were identified from 62 exposed children and 15 control children. Susceptibility testing results revealed that, overall, 72.49% of ETEC colonies were resistant to at least one of the first-line antibiotics. Multiple logistic regression results adjusted for the fact that each child had multiple ETEC colonies and also adjusted for confounding variables showed that for each additional dose of sulfamethoxazole/trimethoprim, the likelihood of having resistant ETEC colonies increased by 64%. The analysis did not show an association between antibiotic consumption and MDR in ETEC colonies, nor with other specific antibiotics. Further research into the causes that contribute to the development of resistance is suggested.
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