Bibliographic citations
Reyes, I., (2015). Asociación del polimorfismo genético de las IL-1A C(889)T Y IL-1B C(+3953/4)T en un grupo de adultos con periodontitis crónica [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/4633
Reyes, I., Asociación del polimorfismo genético de las IL-1A C(889)T Y IL-1B C(+3953/4)T en un grupo de adultos con periodontitis crónica [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2015. https://hdl.handle.net/20.500.12672/4633
@mastersthesis{renati/1209773,
title = "Asociación del polimorfismo genético de las IL-1A C(889)T Y IL-1B C(+3953/4)T en un grupo de adultos con periodontitis crónica",
author = "Reyes Mandujano, Ivonne Fanny",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2015"
}
--- Chronic periodontitis is the most common cause of tooth loss in the world and many risk factors such as infections, inflammatory response, oral hygiene, age, smoking habits and individual genetic characteristics are involved in the development of this disease. The identification of genetic factors that influence oral inflammation may help us understand the predisposition to developing periodontitis. Interleukins, in particular IL-1, are very important in the development of periodontal disease because they are soluble proteins that mediate complex interactions among cells, inflammatory cells and other cellular elements of connective tissue. Therefore the purpose of this study was to determine the association of genetic polymorphisms of the IL-1A C (-889) T, IL-1B C (+3953/4) T, with chronic periodontitis in a group of Peruvians. For this purpose, 94 people with chronic periodontitis and 96 periodontally healthy people were recruits and blood for DNA and perform genotyping of IL-1A and IL-1B, with the PCR-RFLP was extracted to them. Data were analyzed with the test 2, 2 of linear trend and logistic regression with 95% confidence interval. The results show a statistically significant association between positive genotype of the IL-1B and the positive composite genotype with chronic periodontitis. Keywords: Interleukins, cytokines, Chronic Periodontitis, Genetic Polymorphism, PCR-RFLP.
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