Bibliographic citations
Ayala, K., (2024). Influencia del consumo del extracto etanólico de hojas de guanábana (Annona muricata L.) sobre el perfil lipídico en ratas hiperlipidémicas [Universidad Nacional Agraria La Molina]. https://hdl.handle.net/20.500.12996/6278
Ayala, K., Influencia del consumo del extracto etanólico de hojas de guanábana (Annona muricata L.) sobre el perfil lipídico en ratas hiperlipidémicas []. PE: Universidad Nacional Agraria La Molina; 2024. https://hdl.handle.net/20.500.12996/6278
@mastersthesis{renati/1116044,
title = "Influencia del consumo del extracto etanólico de hojas de guanábana (Annona muricata L.) sobre el perfil lipídico en ratas hiperlipidémicas",
author = "Ayala Huamán, Karen Verónica",
publisher = "Universidad Nacional Agraria La Molina",
year = "2024"
}
Cardiovascular diseases are the leading cause of death worldwide and are directly related to hyperlipidemia. It has been reported that plants with a high content of flavonoids can be used for the prevention and treatment of hyperlipidemia and atherosclerosis, due to their antioxidant activity. These bioactive compounds into soursop leaves could have an important impact in the treatment of hyperlipidemia. Thus, the objective of this research was to determine if the ethanolic extract of soursop leaves (Annona muricata L.) has an effect on the lipid profile in Rattus norvergicus with experimentally induced hyperlipidemia. For this, 35 rats were randomly distributed into five treatments. With the exception of the negative control (T0), the other four treatments were induced to hyperlipidemia with 8mg/g of weight monosodium glutamate (MSG) and received the following treatments, (T1) positive control; (T2) and (T3) two different doses of the ethanolic extract of soursop leaves 250 mg/Kg/day and 500 mg/Kg/day respectively and (T4) atorvastatin 1.1 mg/Kg/day as pharmacological control. During the trial, initial and final live weight, weight gain and feed intake were recorded. After 30 days, the lipid profile was measured and the results obtained were subjected to ANOVA under a DCA and the comparison of means was calculated through Duncan´s test, using the SAS 9.0 statistical software. The results showed that final live weight, weight gain and feed intake were influenced by the dietary treatments. Also, the ethanolic extract of soursop leaves significantly decreased (p<0.05) the levels of COL, TG, c-VLDL, c-LDL, coronary risk index and increased the levels of c-HDL, being the dose of 500 mg/Kg the one that presented the greatest effect on comparison to the commercial drug evaluated. In conclusion, the ethanolic extract of soursop leaves has a hypolipidemic effect in rats with experimentally induced hyperlipidemia..
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