Citas bibligráficas
López, J., (2020). Evaluación de la actividad antimalárica in vitro de extractos de especies vegetales del género Piper frente a Plasmodium falciparum, Iquitos, Perú 2019 [Tesis, Universidad Nacional de la Amazonia Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6790
López, J., Evaluación de la actividad antimalárica in vitro de extractos de especies vegetales del género Piper frente a Plasmodium falciparum, Iquitos, Perú 2019 [Tesis]. : Universidad Nacional de la Amazonia Peruana; 2020. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/6790
@misc{renati/287501,
title = "Evaluación de la actividad antimalárica in vitro de extractos de especies vegetales del género Piper frente a Plasmodium falciparum, Iquitos, Perú 2019",
author = "López Mesia, Jhesus Jean Pierre",
publisher = "Universidad Nacional de la Amazonia Peruana",
year = "2020"
}
The dissemination of antimalarial resistant strains highlights the need for new therapeutic alternatives, the present study has as general objective to evaluate the in vitro antimalarial activity of 11 vegetable species of the genus Piper against strains of Plasmodium falciparum. An experimental study was conducted. The ethanolic extracts were obtained from species collected in the Peruvian Amazon. In vitro antimalarial activity was evaluated against to 3D7 and FCR3 strain of Plasmodium falciparum. As a positive control, Chloroquine Diphosphate and the ethanolic extract of the bark of Remijia peruviana were used. Parasitemia was determined by flow cytometry (BD FACScalibur) by staining with ethidium bromide (10 μg/ml). The percentage of inhibition was determined and the IC50 was established by an activity curve: dose-response. (CI = 95%, p = 0.05). Of the 11 plant species studied Piper tridentipilum C. DC. (3D7: 5.24 μg/mL; FCR3: 2.64 μg/mL), Piper stellipilum (Miq.) C. DC. (3D7: 5.32 μg/mL; FCR3: 4.18 μg/mL), Piper longeacuminatum Trel (3D7: 4.69 μg/mL; FCR3: 3.8 μg/mL) and Piper pseudoarboreum Yunck (3D7: 4.25 μg/mL; FCR3: 5.1 μg/mL) presented antimalarial activity against both strains.
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