Citas bibligráficas
Aylas, A., Villacorta, G. (2014). Estudio químico biodirigido in vitro sobre formas parasitarias de Leishmania spp. y Plasmodium falciparum de los extractos y fracciones de las especies de Piper callosum (guayusa) y Unonopsis stipitata (vara caspi) [Tesis, Universidad Nacional de la Amazonia Peruana]. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/3598
Aylas, A., Villacorta, G. Estudio químico biodirigido in vitro sobre formas parasitarias de Leishmania spp. y Plasmodium falciparum de los extractos y fracciones de las especies de Piper callosum (guayusa) y Unonopsis stipitata (vara caspi) [Tesis]. : Universidad Nacional de la Amazonia Peruana; 2014. http://repositorio.unapiquitos.edu.pe/handle/20.500.12737/3598
@misc{renati/276951,
title = "Estudio químico biodirigido in vitro sobre formas parasitarias de Leishmania spp. y Plasmodium falciparum de los extractos y fracciones de las especies de Piper callosum (guayusa) y Unonopsis stipitata (vara caspi)",
author = "Villacorta Barbarán, Gladys Oriana",
publisher = "Universidad Nacional de la Amazonia Peruana",
year = "2014"
}
Endemic parasitie such as the Leishmaniosis and Malaria are the main responsible of the large number of morbidity and mortality in the world area, medicinal plants represent an important alternative due to the find of new antiparasitic drugs. It was determinate of the organics fractions and aqueous of the Piper callosum and Unonopsis stipitata leaves, the organic fractions of Petroleum Eter of Piper callosum represented selective activity fairly assets against L. braziliensis with IC50 of 47.18 μg/mL, different from the dichloromethane organic fraction of Unonopsis stipitata, wich represented activity against the two stumps of Leishmania: L.amazonensis, and L. braziliensis with a IC50 of 30.8 μg/mL and 23.8 μg/mL, respectively, and acording to the range of Leishmania activity are considerated as assets. Among the five organic fractions, the dichloromethane organic fraction of Unonopsis stipitata represented biological activity in vitro over Plasmodium falciparum FCR3 – resistent to Cloroquine with IC50 of 9 μg/ml and a percentage and inhibition of 52%. Between the two medicinal plants, the dichloromethane organic fraction obtained from the Unonopsis stipitata specie was the one that represented the major antimalarial and leishmanicidal activity.
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