Bibliographic citations
Quispe, J., Suazo, F. (2014). Efecto anticonceptivo del extracto etanólico de la semilla de Persea americana (palta) en ratones hembras durante el periodo enero-marzo 2014 [Tesis, Universidad Nacional Mayor de San Marcos]. https://hdl.handle.net/20.500.12672/3688
Quispe, J., Suazo, F. Efecto anticonceptivo del extracto etanólico de la semilla de Persea americana (palta) en ratones hembras durante el periodo enero-marzo 2014 [Tesis]. PE: Universidad Nacional Mayor de San Marcos; 2014. https://hdl.handle.net/20.500.12672/3688
@misc{sunedu/2882483,
title = "Efecto anticonceptivo del extracto etanólico de la semilla de Persea americana (palta) en ratones hembras durante el periodo enero-marzo 2014",
author = "Suazo Pinedo, Fiorella",
publisher = "Universidad Nacional Mayor de San Marcos",
year = "2014"
}
Objective: To determine whether oral administration of ethanolic seed extract of Persea americana (avocado) in female mice has contraceptive effect. Design: Experimental study. Location: Bioterio’s Faculty of Medicine and Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos. Biological material: Mice BALB/c-53 strain. Interventions: Forty female mice were randomly divided into 4 main groups of 10 each. The first control group received Gum Tragacanth (GT) Solution 1% 10mL/kg and the others groups received orally extract at doses of 25mg/kg, 5mg/kg and 100mg/kg, for 16 days. Each group considered 10 females and 2 males together; they were divided into 2 sub - groups of 5 females and 1 male per cage. At day 17 the female mice were sacrificed, to observe the presence of fetuses in the uterus. Also the study photochemical and chromatography of the ethanol extract of Persea americana seed was performed. Main outcome measures: The contraceptive effect was assessed by quantifying the macroscopic indicator pregnancy. Statistical analysis: Statistical analysis was performed using the SPSS software version 20.0 and Excel office 2010. Descriptive analyzes and statistical tests of significance were performed. Results: The saponins and alkaloids were in greater amounts in the ethanol extract, but flavonoids and tannins were presents too. Contraceptive effect with percentage of 30%, 20 % and 0 % at doses of 25, 50 and 100mg/kg per corporal weight, respectively showed. Controls showed 10% of absence of pregnancy. It should be noted that 100% of the female mice receiving the ethanolic extract of the plant to maximum dose was pregnant and the course of pregnancy was highly advanced compared the control group. Conclusions: In experimental conditions, the ethanol extract of seed of Persea americana (avocado) showed a poor contraceptive effect with the lowest dose that was not statistically significant; and increase fertility in normal female mice with highest doses due to observed characteristics. Keywords: Contraceptive, Persea americana, Contraceptive plants.
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